December 2016. Volume 12. Number 4

Acetaminophen or ibuprofen in asthmatic children?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, et al. Acetaminophen versus ibuprofen in young children with mild persistent asthma. N Engl J Med. 2016;375:619-30.

Reviewers: Martín Masot R1, Ortega Páez E2.
1Servicio de Pediatría. Área Hospitalaria de Granada. Granada. España.
2CS Maracena. Distrito Granada-Metropolitano. Granada. España.
Correspondence: Rafael Martín Masot. Email: rafammgr@gmail.com
Reception date: 16/11/2016
Acceptance date: 18/11/2016
Publication date: 23/11/2016

Abstract

Authors´ conclusions: among children with mild persistent asthma, as-needed use of acetaminophen was not found associated with higher incidence of asthma attacks or with worse asthma control than was as-needed use of ibuprofen.

Reviewers´ commentary: this is a well-designed trial that shows no difference in the use of acetaminophen or ibuprofen with respect to asthma attacks or asthma control. There was no placebo group for ethical issues and we cannot know whether or not there is a causal relationship between the use of those drugs and worsening of the course of asthma or worse asthma control, but given the available evidence does not seem sensible to restrict their use in children with asthma.

How to cite this article

Martín Masot R, Ortega Páez E. ¿Parecetamol o ibuprofeno en niños asmáticos? Evid Pediatr. 2016;12:66.

AVC | Critically appraised articles

Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, et al. Acetaminophen versus ibuprofen in young children with mild persistent asthma. N Engl J Med. 2016;375:619-30.

Reviewers: Martín Masot R1, Ortega Páez E2.
1Servicio de Pediatría. Área Hospitalaria de Granada. Granada. España.
2CS Maracena. Distrito Granada-Metropolitano. Granada. España.
Correspondence: Rafael Martín Masot. Email: rafammgr@gmail.com
Reception date: 16/11/2016
Acceptance date: 18/11/2016
Publication date: 23/11/2016

How to cite this article

Martín Masot R, Ortega Páez E. ¿Parecetamol o ibuprofeno en niños asmáticos? Evid Pediatr. 2016;12:66.

References

  1. Asthmanet [en línea] [consultado el 18/11/2016]. Disponible en: http://asthmanetresearch.org/studies.cfm?cat=Children.
  2. Eder W, Ege MJ, von Mutius E. The asthma epidemic. Engl J Med. 2006;355:2226-35.
  3. Henderson AJ, Shaheen SO. Acetaminophen and asthma. Paediatr Respir Rev. 2013;14:9-16.
  4. Sordillo JE, Scirica CV, Rifas-Shiman SL, Rich-Edwards JW, Gillman MW, Bunyavanich S, et al. Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. J Allergy Clin Immunol. 2015; 135: 441-8.
  5. Cheelo M, Lodge CJ, Dharmage SC, Simpson JA, Matheson M, Heinrich J, et al. Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis. Arch Dis Child. 2015; 100:81-9.
23/11/2016

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