December 2009. Volume 5. Number 4

The effectiveness of oseltamivir for the prevention of complications of seasonal influenza In children with chronic diseases, is limited

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Piedra PA, Schulman KL, Blumentals WA. Effects of oseltamivir on influenza-related complications in children with chronic medical conditions. Pediatrics. 2009;124:170-8
Reviewers: Buñuel Álvarez JC1, Gimeno Díaz de Atauri Á2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 16/09/2009
Acceptance date: 30/09/2009
Publication date: 09/12/2009

Abstract

Authors' conclusions: oseltamivir prescribed at influenza diagnosis reduces influenza complications and hospitalizations for children at high risk of influenza complications.

Reviewers' commentary: the effectiveness of oseltamivir for the prevention of complications of seasonal influenza in children with chronic medical conditions is limited. Oseltamivir did not reduce the percentage of admissions for pneumonia and other respiratory diseases other than pneumonia. There is an urgent need of clinical trials in children of risk groups with flu, to determine ithe effectiveness of oseltamivir int the prevention of complicantions.

How to cite this article

Buñuel Álvarez JC, Gimeno Díaz de Atauri A. En niños con enfermedades crónicas, la efectividad de oseltamivir para la prevención de complicaciones secundarias a la gripe estacional parece muy limitada. Evid Pediatr. 2009;5:81.

AVC | Critically appraised articles

Piedra PA, Schulman KL, Blumentals WA. Effects of oseltamivir on influenza-related complications in children with chronic medical conditions. Pediatrics. 2009;124:170-8
Reviewers: Buñuel Álvarez JC1, Gimeno Díaz de Atauri Á2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 16/09/2009
Acceptance date: 30/09/2009
Publication date: 09/12/2009

How to cite this article

Buñuel Álvarez JC, Gimeno Díaz de Atauri A. En niños con enfermedades crónicas, la efectividad de oseltamivir para la prevención de complicaciones secundarias a la gripe estacional parece muy limitada. Evid Pediatr. 2009;5:81.

References

  1. Shun-Shin M, Thompson M, Heneghan C, Perera R, Harnden A, Mant D. Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials. BMJ. 2009;339:b3172.
  2. Asociación Española de Pediatría (AEP). Grupo de Trabajo de Pediatría Basada en la Evidencia (GT-PBE). Informe técnico en pediatría sobre la gripe pandémica A (H1N1) [actualizado 7/11/2009][consultado: 16/11/2009]. Disponible en: http://www.aeped.es/gripe/pdf/capitulo_2.pdf
  3. WHO Guidelines for pharmacological management of pandemic (H1N1) 2009 influenza and other influenza virases. 20 August 2009 [consultado: 16/11/2009]. Disponible en: http://www.who.int/csr/resources/publications/swineflu/h1n1_guidelines_pharmaceutical_mngt.pdf
  4. Centers for Disease Control and Prevention. Updated Interim Recommendations for the Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009-2010 Season. October 16, 2009 [consultado: 16/11/2009]. Disponible en: http://www.cdc.gov/H1N1flu/recommendations.htm
09/12/2009

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