June 2010. Volume 6. Number 2

Acellular pertussis vaccine, administered at birth and at one month of life, induces detectable titles of antibodies against pertussis toxin at two months of age

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wood N, McIntyre P, Marshall H, Roberton D. Acellular pertussis vaccine at birth and one month induces antibody responses by two months of age. Pediatr Infect Dis J. 2010;29:209-15
Reviewers: Buñuel Álvarez JC1, Guarch Ibáñez B2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Hospital Universitario de Girona Dr. Josep Trueta. GIRONA. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 01/06/2010
Acceptance date: 08/06/2010
Publication date: 21/06/2010

Abstract

Authors’ conclusions: acellular pertussis vaccine administered at birth and one month produces a detectable immune response at two months of age.

Reviewers’ commentary: the results of this pilot trial are encouraging because they demonstrate seroconversion when acellular vaccine against pertussis is administered at birth and at two months old. However, these results should be confirmed in a clinical trial to solve the methodological limitations of this study.This trial should determine whether the seroconversion is clinically protective and if the pattern of administration interferes with seroconversion against other vaccine antigens.

How to cite this article

Buñuel Álvarez JC, Guarch Ibáñez B. La vacuna acelular de la tos ferina, administrada al nacimiento y al mes de vida, es eficaz para obtener títulos detectables de anticuerpos antitoxina pertussis a los dos meses de edad. Evid Pediatr. 2010;6:29.

AVC | Critically appraised articles

Wood N, McIntyre P, Marshall H, Roberton D. Acellular pertussis vaccine at birth and one month induces antibody responses by two months of age. Pediatr Infect Dis J. 2010;29:209-15
Reviewers: Buñuel Álvarez JC1, Guarch Ibáñez B2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Hospital Universitario de Girona Dr. Josep Trueta. GIRONA. Girona. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 01/06/2010
Acceptance date: 08/06/2010
Publication date: 21/06/2010

How to cite this article

Buñuel Álvarez JC, Guarch Ibáñez B. La vacuna acelular de la tos ferina, administrada al nacimiento y al mes de vida, es eficaz para obtener títulos detectables de anticuerpos antitoxina pertussis a los dos meses de edad. Evid Pediatr. 2010;6:29.

References

  1. Crowcroft N, Stein C, Duclos P, Birmingham M. How to best estimate the global burden of pertussis? Lancet Infect Dis. 2003;3:413-8.
  2. Préziosi MP, Yam A, Wassilak SG, Chabirand L, Simaga A, Ndiaye M, et al. Epidemiology of pertussis in a West African community before and after introduction of a widespread vaccination program. Am J Epidemiol. 2002;155:891-6.
  3. Red Nacional de Vigilancia Epidemiológica. Situación de la tos ferina en España [actualizado jun 2009] [consultado 28 may 2010].Disponible en:  http://www.isciii.es/htdocs/centros/epidemiologia/pdf/Informetosferinajunio2009.pdf
  4. Murphy T, Slade B, Broder K, Kretsinger K, Tiwari T, Joyce PM; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-4):1-51.
21/06/2010

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