September 2010. Volume 6. Number 3

Target oxygen saturation too low may increase the mortality of extremely premature despite lowering the risk of retinopathy

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Support study group of the Eurice Kennedy Shriver NICHD. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010;362:1959-69
Reviewers: Aparicio Rodrigo M1, Balaguer Santamaría A2.
1 Centro de Salud Entreví­as. Área 1. Madrid. España.
2H General Catalunya. Sant Cugat del Vallés. Barcelona. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Acceptance date: 12/08/2010
Publication date: 18/08/2010

Abstract

Authors' conclusions: in preterm infants between 24 and 28 weeks of gestation, low oxygen saturations (85-95% vs 91-95%) significantly reduced the incidence of severe retinopathy among survivors, but increase mortality. The increased mortality with low oxygen saturations is a factor to be taken into account when treating these patients.

Reviewers' commentary: This study is a warning about the effects that the administration of very low oxygen saturations (85-89%) may have on mortality. So far, the results of this study recommend that for extreme preterm infants, intermediate target saturations could be the safest.

How to cite this article

Aparicio Rodrigo M, Balaguer A. Saturaciones diana de oxígenodemasiado bajas podrían aumentar la mortalidad delos prematurosextremos a pesar de disminuir el riesgo de retinopatía-  Evid Pediatr. 2010;6:61.

AVC | Critically appraised articles

Support study group of the Eurice Kennedy Shriver NICHD. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010;362:1959-69
Reviewers: Aparicio Rodrigo M1, Balaguer Santamaría A2.
1 Centro de Salud Entreví­as. Área 1. Madrid. España.
2H General Catalunya. Sant Cugat del Vallés. Barcelona. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Reception date:
Acceptance date: 12/08/2010
Publication date: 18/08/2010

How to cite this article

Aparicio Rodrigo M, Balaguer A. Saturaciones diana de oxígenodemasiado bajas podrían aumentar la mortalidad delos prematurosextremos a pesar de disminuir el riesgo de retinopatía-  Evid Pediatr. 2010;6:61.

References

  1. Chow LC, Wright KW, Sola A. Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics. 2003;111:339-45.
  2. Asie LM, Henderson-Smart DJ, Irving L, Simpson JM. Oxigen saturation targets and outcomes in estremely preterm infants. N Engl J Med. 2003:349:959-67.
  3. Askie LM, Henderson-Smart DJ, Ko H. Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birth weight infants. Cochrane Database of Systematic Reviews. 2009, Issue 1. Art. No.: CD001077. DOI: 10.1002/14651858.CD001077.pub2
18/08/2010

Linked Comment