June 2012. Volume 8. Number 2

Hypothyroidism’s universal screening during pregnancy does not improve cognitive function in children at 3 years of age

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A et al. Antenatal thyroid screening and childhood cognitive function. N Engl J Med. 2012;366(6):493-501.
Reviewers: Aizpurua Galdeano P1, Aparicio Rodrigo M2.
1ABS 7 La Salut Badalona. Badalona. Barcelona. España.
2Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 05/05/2012
Acceptance date: 11/05/2012
Publication date: 23/05/2012

Abstract

Authors’ conclusions: antenatal screening at gestational age of 12 weeks and maternal treatment for hypothyroidism did not result in improved cognitive function in children at 3 years of age.

Reviewers' commentary: treatment of women with subclinical hypothyroidism in the late first trimester does not seem to improve their children's IQ at 3 years of age. These results support the current guideline recommendations against universal screening for hypothyroidism during pregnancy. However, it would be advisable to wait for the performance of the follow up expected at five and seven years of age.

How to cite this article

Aizpurua Galdeano P, Aparicio Rodrigo M. El cribado universal de hipotiroidismo en gestantes no mejora el coeficiente intelectual de sus hijos a los tres años. Evid Pediatr. 2012;8:41.

AVC | Critically appraised articles

Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A et al. Antenatal thyroid screening and childhood cognitive function. N Engl J Med. 2012;366(6):493-501.
Reviewers: Aizpurua Galdeano P1, Aparicio Rodrigo M2.
1ABS 7 La Salut Badalona. Badalona. Barcelona. España.
2Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 05/05/2012
Acceptance date: 11/05/2012
Publication date: 23/05/2012

How to cite this article

Aizpurua Galdeano P, Aparicio Rodrigo M. El cribado universal de hipotiroidismo en gestantes no mejora el coeficiente intelectual de sus hijos a los tres años. Evid Pediatr. 2012;8:41.

References

  1. de Escobar GM, Obregón MJ. Consecuencias de la deprivación de iodo y hormonas tiroideas. Monografía publicada por la Real Academia Nacional de Farmacia. Portal Publicaciones [en línea] [fecha de consulta: 15-IV-2012]. Disponible en: http://www.analesranf.com/index.php/mono/article/viewFile/610/627366:493-501.
  2. Vissenberg R, van den Boogaard E, van Wely M, van der Post JA, Fliers E, Bisschop PH et al. Treatment of thyroid disorders before conception and in early pregnancy: a systematic review. Hum Reprod Update. 2012 Mar 19. [Epub ahead of print].
  3. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341:549-55.
  4. Henrichs J, Bongers-Schokking JJ, Schenk JJ, Ghassabian A, Schmidt HG, Visser TJ et al. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. J Clin EndocrinolMetab. 2010;95(9):4227-34.
  5. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081-125.
23/05/2012

Linked Comment