June 2015. Volume 11. Number 2

Is dexamethasone an alternative to prednisone in the treatment of asthma attacks?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, et al. Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis. Pediatrics. 2014;133:493-9.
Reviewers: Albi Rodríguez MS1, Gimeno Díaz de Atauri Á2.
1Neumología pediátrica. H. Hospital Universitario Infanta Leonor. Madrid. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: María Salomé Albi Rodríguez. Email: msalbir@gmail.com
Reception date: 23/03/2015
Acceptance date: 27/03/2015
Publication date: 08/04/2015

Abstract

Authors’ conclusions: in pediatric patients with acute asthma exacerbations practitioners should consider single or 2-dose regimens of dexamethasone as a viable alternative to a 5-day course of prednisone/prednisolone.

Reviewers’ commentary: changes in which corticosteroid should be used for asthma attacks are not yet justified. Well-designed clinical trials comparing acceptance, vomiting or other adverse effects should be carried out.Also adequate non-inferiority trials, focusing on clinical variables or costs, must be done with dexamethasone against standard treatment.

How to cite this article

Albi Rodríguez S, Gimeno Díaz de Atauri A. ¿Es la dexametasona una alternativa a la prednisona en el tratamiento de las crisis asmáticas? Evid Pediatr. 2015;11:27.

AVC | Critically appraised articles

Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, et al. Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis. Pediatrics. 2014;133:493-9.
Reviewers: Albi Rodríguez MS1, Gimeno Díaz de Atauri Á2.
1Neumología pediátrica. H. Hospital Universitario Infanta Leonor. Madrid. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: María Salomé Albi Rodríguez. Email: msalbir@gmail.com
Reception date: 23/03/2015
Acceptance date: 27/03/2015
Publication date: 08/04/2015

How to cite this article

Albi Rodríguez S, Gimeno Díaz de Atauri A. ¿Es la dexametasona una alternativa a la prednisona en el tratamiento de las crisis asmáticas? Evid Pediatr. 2015;11:27.

References

  1. British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 2014;69:1-192.
  2. Butler K, Cooper WO. Adherence of pediatric asthma patients with oral corticosteroid prescriptions following pediatric emergency department visit or hospitalization. Pediatr Emerg Care. 2004;20:730-5.
  3. Andrews AL, Wong KA, Heine D, Scott Russell W. A cost-effectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations. Acad Emerg Med. 2012;8:943-8.
08/04/2015

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