March 2024. Volume 20. Number 1

Proton pump inhibitors and risk for serious infections in children: time heals all

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Lassalle M, Zureik M, Dray-Spira R. Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children. JAMA Pediatr. 2023. 1;177:1028-38.

Reviewers: Llerena Santa Cruz E1, Pérez-Moneo Agapito B2.
1Pediatra CAP La Torrassa. L'Hospitalet de Llobregat. Barcelona. Hospital Joan XXIII . Tarragona. España.
2Servicio de Pediatría. Hospital Universitario Infanta Leonor. Universidad Complutense de Madrid. Madrid. España.
Correspondence: Enrique Llerena Santa Cruz. Email: kikellerena@gmail.com
Reception date: 16/12/2023
Acceptance date: 15/01/2024
Publication date: 24/01/2024

Abstract

Authors´conclusions: in this study, proton pump inhibitors use was associated with an increased risk of serious infections in young children. Proton pump inhibitors should not be used without a clear indication in this population.

Reviewers´commentary: proton pump inhibitors slightly increase the risk of serious infections in children when they are first taken and during treatment. This relationship seems less relevant when treatment has finished. Its use should be limited to patients with a clear indication.

How to cite this article

Llerena Santa Cruz E, Begoña Pérez-Moneo Agapito B. Los inhibidores de bomba de protones y el riesgo de infecciones graves en niños: el tiempo lo cura todo. Evid Pediatr. 2024;20:6.

AVC | Critically appraised articles

Lassalle M, Zureik M, Dray-Spira R. Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children. JAMA Pediatr. 2023. 1;177:1028-38.

Reviewers: Llerena Santa Cruz E1, Pérez-Moneo Agapito B2.
1Pediatra CAP La Torrassa. L'Hospitalet de Llobregat. Barcelona. Hospital Joan XXIII . Tarragona. España.
2Servicio de Pediatría. Hospital Universitario Infanta Leonor. Universidad Complutense de Madrid. Madrid. España.
Correspondence: Enrique Llerena Santa Cruz. Email: kikellerena@gmail.com
Reception date: 16/12/2023
Acceptance date: 15/01/2024
Publication date: 24/01/2024

How to cite this article

Llerena Santa Cruz E, Begoña Pérez-Moneo Agapito B. Los inhibidores de bomba de protones y el riesgo de infecciones graves en niños: el tiempo lo cura todo. Evid Pediatr. 2024;20:6.

24/01/2024

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