December 2009. Volume 5. Number 4

Antibiotic prophylaxis with trimethoprim-sulfamethoxazole may decrease slightly the recurrence of urinary infection, although it is unclear  whether our patients would benefit from it

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Craig JC, Simpson JM, Williams GJ, Lowe A, Reynolds GJ, McTaggart SJ, et al. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009;361:1748-59
Reviewers: Ochoa Sangrador C1, Buñuel Álvarez JC2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: /11/2009
Acceptance date: 15/11/2009
Publication date: 10/12/2009

Abstract

Authors' conclusions: antibiotic prophylaxis with TS is associated with a decrease of recurrence in children with UTIs in predisposed children. The selective use of TS prophylaxis in children at high risk of recurrence is recommended.

Reviewers' commentary: there are doubts about the clinical impact of treatment: minimal reduction in the recurrence of UTI, no effect on renal damage and increased risk of UTI with resistant organisms. Studies are needed to determine the effectiveness of risk in homogeneous groups in order to establish recommendations in our geographical area.

How to cite this article

Ochoa Sangrador C, Buñuel Álvarez JC. La profilaxis antibiótica podría disminuir discretamente la recurrencia de infección urinaria, aunque no está claro si nuestros pacientes se beneficiarían de ella. Evid Pediatr. 2009;5:84.

AVC | Critically appraised articles

Craig JC, Simpson JM, Williams GJ, Lowe A, Reynolds GJ, McTaggart SJ, et al. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009;361:1748-59
Reviewers: Ochoa Sangrador C1, Buñuel Álvarez JC2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: /11/2009
Acceptance date: 15/11/2009
Publication date: 10/12/2009

How to cite this article

Ochoa Sangrador C, Buñuel Álvarez JC. La profilaxis antibiótica podría disminuir discretamente la recurrencia de infección urinaria, aunque no está claro si nuestros pacientes se beneficiarían de ella. Evid Pediatr. 2009;5:84.

References

  1. Williams G, Wei L, Lee A, Craig JC. Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD001534. DOI: 10.1002/14651858.CD001534.pub2.
  2. Montini G, Rigon L, Zucchetta P, Fregonese F, Toffolo A, Gobber D, et al. Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled noninferiority trial. Pediatrics 2008;122:1064-71.
  3. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 2006;117:626-32.
10/12/2009

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