June 2011. Volume 7. Number 2

Fetal surgery can improve the prognosis of children with myelomeningocele

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Adzick NS, Thom EA, Spong CY, Brock JW, Burrows PK, Johnson MP; the MOMS Investigators. A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele. N Engl J Med. 2011 Feb 9. [Epub ahead of print].
Reviewers: González de Dios J1, Buñuel Álvarez JC2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 14/03/2011
Acceptance date: 16/03/2011
Publication date: 23/03/2011

Abstract

Authors' conclusions: prenatal surgery for myelomeningocele reduced the need for referral and improved motor outcomes at 30 months but was associated with maternal and fetal risks.

Reviewers' commentary: modern techniques of fetal surgery as those carried out in this study seem to improve significantly the prognosis of these children, decreasing the morbidity associated to the malformation. More than 30 months follow-up studies are needed to determine the impact of fetal surgery on long term psychomotor development.

How to cite this article

González de Dios J, Buñuel Álvarez JC. La cirugía fetal puede mejorar el pronóstico de los niños con mielomeningocele. Evid Pediatr. 2011;7:32.

AVC | Critically appraised articles

Adzick NS, Thom EA, Spong CY, Brock JW, Burrows PK, Johnson MP; the MOMS Investigators. A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele. N Engl J Med. 2011 Feb 9. [Epub ahead of print].
Reviewers: González de Dios J1, Buñuel Álvarez JC2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 14/03/2011
Acceptance date: 16/03/2011
Publication date: 23/03/2011

How to cite this article

González de Dios J, Buñuel Álvarez JC. La cirugía fetal puede mejorar el pronóstico de los niños con mielomeningocele. Evid Pediatr. 2011;7:32.

References

  1. O’Brien PC. Procedures for comparing simples with multiple endpoints. Biometrics. 1984;40:1079-87.
  2. González de Dios J, González Rodríguez P. Evaluación de artículos científicos sobre intervenciones terapéuticas. Evid Pediatr. 2006;2:90.
  3. Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ et al. Fetal myelomeningocele repair: short-term clinical outcomes. Am J Obstet Gynecol. 2003;189:482-7.
  4. Johnson MP, Gerdes M, Rintoul N, Pasquariello P, Melchionni J, Sutton LN et al. Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age. Am J Obstet Gynecol. 2006;194:1145-50.
  5. Danzer E, Gerdes M, Bebbington MW, Sutton LN, Melchionni J, Adzick NS et al. Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery. Fetal Diagn Ther. 2009; 25:47-53.

Related Articles

ED | Fetal surgery: evidence and experience

De Agustín-Asensio JC. Estado actual de la cirugía fetal: evidencias y experiencias. Evid Pediatr 2011;7:28.
23/03/2011

Linked Comment