December 2014. Volume 10. Number 4

A prolonged course of glucocorticoids did not reduce relapses in children with steroid-sensitive nephrotic syndrome

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Sinha A, Saha A, Kumar M, Sharma S, Afzal K, Mehta A, et al. Extending initial prednisolone treatment in a randomized control trial from 3 to 6 months did not significantly influence the course of illness in children with steroid-sensitive nephrotic syndrome. Kidney Int. 2014;16 :1-8.
Reviewers: Corrales Cambero IM1, Pérez Gaxiola G2.
1Hospital Pediátrico de Sinaloa. Culiacán. México.
2Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
Correspondence: Iyali Corrales Cambero. Email: magy_icc@hotmail.com
Reception date: 02/09/2014
Acceptance date: 11/09/2014
Publication date: 15/09/2014

Abstract

Authors' conclusion: extending the initial prednisolone treatment from 3 to 6 months does not have a significant effect in the rate of relapses, frequent relapses, use of steroid saving agents, or remission at one year of follow up.

Reviewers' commentary: a prolonged course of 6 months of prednisolone did not reduce relapses. In a post hoc subgroup analysis by age, children under 3 years old were found to have more remission time until their first relapse. This requires further study.

How to cite this article

Corrales Cambero IM, Pérez Gaxiola G. Prolongar la terapia con prednisolona en niños con síndrome nefrótico corticosensible no reduce las recaídas. Evid Pediatr. 2014;10:66.

AVC | Critically appraised articles

Sinha A, Saha A, Kumar M, Sharma S, Afzal K, Mehta A, et al. Extending initial prednisolone treatment in a randomized control trial from 3 to 6 months did not significantly influence the course of illness in children with steroid-sensitive nephrotic syndrome. Kidney Int. 2014;16 :1-8.
Reviewers: Corrales Cambero IM1, Pérez Gaxiola G2.
1Hospital Pediátrico de Sinaloa. Culiacán. México.
2Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
Correspondence: Iyali Corrales Cambero. Email: magy_icc@hotmail.com
Reception date: 02/09/2014
Acceptance date: 11/09/2014
Publication date: 15/09/2014

How to cite this article

Corrales Cambero IM, Pérez Gaxiola G. Prolongar la terapia con prednisolona en niños con síndrome nefrótico corticosensible no reduce las recaídas. Evid Pediatr. 2014;10:66.

References

  1. Hodson EM, Willis NS, Craig JC. Corticosteroid therapy for nephrotic syndrome in children. Cochrane Database Syst Rev. 2007;4:CD001533.
  2. Teeninga N, Kist-van Holthe JE, van Rijswijk N, de Mos NI, Hop WC, Wetzels JF, et al. Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. J Am Soc Nephrol. 2013;24:149-59.
  3. Hiraoka M, Tsukahara H, Haruki S, Hayashi S, Takeda N, Miyagawa K, et al. Older boys benefit from higher initial prednisolone therapy for nephrotic syndrome. The West Japan Cooperative Study of Kidney Disease in Children. Kidney Int. 2000;58:1247-52.
  4. Saadeh SA, Baracco R, Jain A, Kapur G, Mattoo TK, Valentini RP. Weight or body surface area dosing of steroids in nephrotic syndrome: is there an outcome difference? Pediatr Nephrol. 2011;26:2167-71.
15/09/2014

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