December 2018. Volume 14. Number 3

In children with diabetic ketoacidosis, it is possible to shorten the replacement of the deficit and to use a 0.45% NaCI solution, without producing neurological injury

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, et al. Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis. N Engl J Med. 2018;378:2275-87.

Reviewers: de Lucas García N1, Flores Villar S2.
1SAMUR. Protección Civil. Madrid. España.
2Hospital Universitari Mútua de Terrassa. Barcelona. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 11/08/2018
Acceptance date: 05/10/2018
Publication date: 14/11/2018

Abstract

Authors’ conclusions: neither the content of sodium chloride nor the infusion rate of intravenous fluid therapy influenced the appearance of early or late neurological adverse effects in children with diabetic ketoacidosis.

Reviewers’ commentary: in children with diabetic ketoacidosis and with a Glasgow Coma Scale (GCS) score of >11, the replacement time of the volume deficit can be shortened and 0.45% saline can be used, without producing neurological damage. It would be convenient to carry out new studies that help us to better define the subgroups that would benefit from each type of replacement.

How to cite this article

De Lucas García N, Flores Villar S. En niños con cetoacidosis diabética, se puede acortar la reposición del déficit y usar suero salino al 0,45% sin producir daño neurológico. Evid Pediatr. 2018;14:35.

AVC | Critically appraised articles

Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, et al. Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis. N Engl J Med. 2018;378:2275-87.

Reviewers: de Lucas García N1, Flores Villar S2.
1SAMUR. Protección Civil. Madrid. España.
2Hospital Universitari Mútua de Terrassa. Barcelona. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 11/08/2018
Acceptance date: 05/10/2018
Publication date: 14/11/2018

How to cite this article

De Lucas García N, Flores Villar S. En niños con cetoacidosis diabética, se puede acortar la reposición del déficit y usar suero salino al 0,45% sin producir daño neurológico. Evid Pediatr. 2018;14:35.

14/11/2018

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