December 2019. Volume 15. Number 4

Proton pump inhibitors and increased fracture hazard. Another reason for an appropriate prescription of these drugs

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Malchodi L, Wagner K, Susi A, Gorman G, Hisle-Gorman E. Early acid suppression therapy exposure and fracture in young children. Pediatrics. 2019;144: e20182625.

Reviewers: Molina Arias M1, Pérez-Moneo Agapito B2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2Servicio de Pediatría. Hospital Universitario Infanta Leonor. Madrid. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 12/11/2019
Acceptance date: 27/11/2019
Publication date: 04/12/2019

Abstract

Authors’ conclusions: infant proton pump inhibitors alone or together with H2 receptor antagonists is associated with an increased childhood fracture risk. This risk appears amplified by duration or early initiation of the therapy.

Reviewers’ commentary: the increased risk of fractures associated with antisecretory treatment during the first year of life another argument to carefully assess the indication of these drugs, especially proton pump inhibitors, particularly in treatments at an early age or long-term treatments.

How to cite this article

Cómo citar este artículo: Molina Arias M, Pérez-Moneo Agapito B. Riesgo de fractura e inhibidores de bomba de protones: otra razón para un uso adecuado. Evid Pediatr. 2019;15:45.

AVC | Critically appraised articles

Malchodi L, Wagner K, Susi A, Gorman G, Hisle-Gorman E. Early acid suppression therapy exposure and fracture in young children. Pediatrics. 2019;144: e20182625.

Reviewers: Molina Arias M1, Pérez-Moneo Agapito B2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2Servicio de Pediatría. Hospital Universitario Infanta Leonor. Madrid. España.
Correspondence: Manuel Molina Arias. Email: mma1961@gmail.com
Reception date: 12/11/2019
Acceptance date: 27/11/2019
Publication date: 04/12/2019

How to cite this article

Cómo citar este artículo: Molina Arias M, Pérez-Moneo Agapito B. Riesgo de fractura e inhibidores de bomba de protones: otra razón para un uso adecuado. Evid Pediatr. 2019;15:45.

04/12/2019

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