June 2021. Volume 17. Number 2

Valaciclovir prevents the transmission of cytomegalovirus from the pregnant woman to the fetus during the first trimester

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, et al. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial. Lancet. 2020;396:779-85.

Reviewers: Flores Villar S1, García Vera C2.
1Unidad de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Pediatra. CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 13/04/2021
Acceptance date: 27/04/2021
Publication date: 12/05/2021

Abstract

Authors' conclusions: valaciclovir, in pregnant women with primary cytomegalovirus infection in early pregnancy, is effective in reducing the rate of fetal infection. Its administration in early stages of pregnancy can prevent pregnancy terminations and newborns with congenital infection by the virus.

Reviewers' commentary: this randomized clinical trial seems to demonstrate that the administration of Valaciclovir in pregnant women infected with cytomegalovirus during the first trimester of gestation significantly reduces the probability of fetal infection. However, there are no significant differences in clinical manifestations in infants between the intervention and control groups.

How to cite this article

Flores Villar S, García Vera C.Valaciclovir previene la transmisión del citomegalovirus de la embarazada al feto durante el primer trimestre. Evid Pediatr. 2021;17:22.

AVC | Critically appraised articles

Shahar-Nissan K, Pardo J, Peled O, Krause I, Bilavsky E, Wiznitzer A, et al. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial. Lancet. 2020;396:779-85.

Reviewers: Flores Villar S1, García Vera C2.
1Unidad de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Pediatra. CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 13/04/2021
Acceptance date: 27/04/2021
Publication date: 12/05/2021

How to cite this article

Flores Villar S, García Vera C.Valaciclovir previene la transmisión del citomegalovirus de la embarazada al feto durante el primer trimestre. Evid Pediatr. 2021;17:22.

12/05/2021

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