March 2025. Volume 21. Number 1

New vaccine with adjuvant against respiratory syncytial virus for pregnant women: effective but doubtfully safe

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Dieussaert I, Hyung Kim J, Luik S, Seidl C, Pu W, Stegmann JU, et al. RSV Prefusion F Protein-Based Maternal Vaccine - Preterm Birth and Other Outcomes. N Engl J Med. 2024;390(11):1009-21.

Reviewers: Oltra Benavent M1, Ochoa Sangrador C2.
1Sección de Patología Infecciosa Infantil. Hospital Universitari i Politècnic La Fe. Valencia. España.
2Servicio de Pediatría. Complejo Asistencial de Zamora. Zamora. España.
Correspondence: Manuel Oltra Benavent . Email: oltra.benavent@gmail.com
Reception date: 07/01/2025
Acceptance date: 13/01/2025
Publication date: 29/01/2025

Abstract

Authors´ conclusions: this maternal vaccine against respiratory syncytial virus reduces the risk of medically assessed lower respiratory tract disease among infants but increases the risk of preterm birth.

Reviewers´ commentary: an important safety alert regarding a higher incidence of prematurity after administration of this vaccine triggers the termination rule for this study and conditions the magnitude of its efficacy in reducing the risk of respiratory syncytial virus infection.

How to cite this article

Oltra Benavent M, Ochoa Sangrador C. Nueva vacuna con coadyuvante frente al virus respiratorio sincitial en la gestante: eficaz pero dudosamente segura. Evid Pediatr. 2025;21:4.

AVC | Critically appraised articles

Dieussaert I, Hyung Kim J, Luik S, Seidl C, Pu W, Stegmann JU, et al. RSV Prefusion F Protein-Based Maternal Vaccine - Preterm Birth and Other Outcomes. N Engl J Med. 2024;390(11):1009-21.

Reviewers: Oltra Benavent M1, Ochoa Sangrador C2.
1Sección de Patología Infecciosa Infantil. Hospital Universitari i Politècnic La Fe. Valencia. España.
2Servicio de Pediatría. Complejo Asistencial de Zamora. Zamora. España.
Correspondence: Manuel Oltra Benavent . Email: oltra.benavent@gmail.com
Reception date: 07/01/2025
Acceptance date: 13/01/2025
Publication date: 29/01/2025

How to cite this article

Oltra Benavent M, Ochoa Sangrador C. Nueva vacuna con coadyuvante frente al virus respiratorio sincitial en la gestante: eficaz pero dudosamente segura. Evid Pediatr. 2025;21:4.

29/01/2025

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