March 2025. Volume 21. Number 1

Exposure to perfluoroalkylated substances in infants is associated with potentially unfavorable adiposity changes in adults

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Van Beijsterveldt IALP, Van Zelst BD, Dorrepaal DJ, Van den Berg SAA, Hokken-Koelega ACS. Early life poly- and perfluoroalkyl substance levels and adiposity in the first 2 years of life. Eur J Endocrinol. 2024;190:338-46.

Reviewers: Rivero Martín MJ1, Aparicio Rodrigo M2.
1Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Departamento de Medicina. Universidad Rey Juan Carlos. Fuenlabrada. Madrid. España.
2Pediatra. CS Entrevías. Facultad de Medicina. Universidad Complutense de Madrid. Madrid. España.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 02/12/2024
Acceptance date: 10/12/2024
Publication date: 15/01/2025

Abstract

Authors´ conclusions: higher Poly-and perfluoroalkyl levels in early life are associated with accelerated gains in fat mass percentage during the first six months of life and with lower fat free mass at the age of two years. Both situations have been associated with an unfavorable body composition and metabolic profile later in life.

Reviewers´ commentary: the results of this study show that breastfeeding is a perfluoroalkyl and polyfluoroalkyl substance exposure pathway in infants. There is a relationship between the highest levels of this substances and the rapid gain of fat mass at six months of life. It will be necessary to assess whether these findings affect the protective effect of breastfeeding on the development of obesity and cardiovascular disease in adulthood.

How to cite this article

Rivero Martín MJ, Aparicio Rodrigo M. La exposición a sustancias perfluoroalquiladas en lactantes se asocia a cambios en la adiposidad potencialmente desfavorables en adultos. Evid Pediatr. 2025;21:2.

AVC | Critically appraised articles

Van Beijsterveldt IALP, Van Zelst BD, Dorrepaal DJ, Van den Berg SAA, Hokken-Koelega ACS. Early life poly- and perfluoroalkyl substance levels and adiposity in the first 2 years of life. Eur J Endocrinol. 2024;190:338-46.

Reviewers: Rivero Martín MJ1, Aparicio Rodrigo M2.
1Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Departamento de Medicina. Universidad Rey Juan Carlos. Fuenlabrada. Madrid. España.
2Pediatra. CS Entrevías. Facultad de Medicina. Universidad Complutense de Madrid. Madrid. España.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 02/12/2024
Acceptance date: 10/12/2024
Publication date: 15/01/2025

How to cite this article

Rivero Martín MJ, Aparicio Rodrigo M. La exposición a sustancias perfluoroalquiladas en lactantes se asocia a cambios en la adiposidad potencialmente desfavorables en adultos. Evid Pediatr. 2025;21:2.

15/01/2025

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