Authors' conclusion: there does not seem to bean increased risk of orofacial clefts associated with the use of corticosteroids during pregnancy. The association between cleft lip with / without cleft palate and dermatological use of corticosteroids during pregnancy may be due to chance, as the result of multiple statistical comparisons, without implying a causal relationship.
Reviewers' commentary: the resultsof this study may permit the use of steroids in those pregnant women, in whom the treatment of certain diseases makes absolutely essential their use. The presence of other potential adverse effects of corticosteroids during pregnancy (e.g. fetal growth retardation, low birth weight) recommends extreme caution with the use of these drugs.