March 2016. Volume 12. Number 1

Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón

 
 
 
 
 
 
 
 
 
 
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Authors: García-Alix A1, Arnaez Solís J2.
1Servicio de Neonatología. Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona. España.
2Hospital Universitario de Burgos. Burgos. España.
Correspondence: Alfredo García-Alix. Email: agarciaalix@hsjdbcn.org
Publication date: 24/02/2016

CA | Associated comment

Authors: García-Alix A1, Arnaez Solís J2.
1Servicio de Neonatología. Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona. España.
2Hospital Universitario de Burgos. Burgos. España.
Correspondence: Alfredo García-Alix. Email: agarciaalix@hsjdbcn.org
Publication date: 24/02/2016

How to cite this article

García-Alix A, Arnaez Solís J. Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón. Evid Pediatr. 2016;12:14.

References

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  2. Gunn AJ, Gunn TR, De Haan HH, Williams CE, Gluckman PD. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997;99:248-56.
  3. Blanco D, Garcia-Alix A, Valverde E, Tenorio V, Vento M, Cabañas F, et al. Neuroprotección con hipotermia en el recién nacido con encefalopatía hipóxico-isquémica. Guía de estándares para su aplicación clínica. An Pediatr (Barc). 2011;75:341.e1-20.
  4. Tagin MA, Woolcott CG, Vincer MJ, Whyte RK,Stinson DA. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2012;166:558-66.
  5. Dworschak M. Pharmacologic neuroprotection-is xenon the light at the end of the tunnel? Crit Care Med. 2008;36:2477-9.
  6. Dinse A, Föhr KJ, Georgieff M, Beyer C, Bulling A, Weigt HU. Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones. Br J Anaesth. 2005;94:479-85.
  7. Chakkarapani E, Dingley J, Liu X, Hoque N, Aquilina K, Porter H, Thoresen M. Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann Neurol. 2010;68:330-41.
  8. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, et al. Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol. 2011;70:133-50.
  9. Sabir H, Walløe L, Dingley J, Smit E, Liu X, Thoresen M. Combined treatment of xenon and hypothermia in newborn rats–additive or synergistic effect? PLoS One. 2014;9:e109845.
  10. Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. 2008;39:1307-13.
  11. Dingley J, Tooley J, Liu X, Scull-Brown E, Elstad M, Chakkarapani E, et al. Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. 2014;133:809-18.
  12. Ochoa C, González de Dios J. El xenón inhalado no parece mejorar el efecto de la hipotermia tras la asfixia perinatal. Evid Pediatr. 2016;12:4.
  13. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deleri A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016;15: 145-53.

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AVC | Inhaled xenon does not seem to improve the effect of cooling after birth asphyxia

Ochoa Sangrador C, González de Dios J. El xenón inhalado no parece mejorar el efecto de la hipotermia tras la asfixia neonatal. Evid Pediatr. 2016;12:4.
24/02/2016

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