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Evidencias en Pediatría (EP / Evidences in Pediatrics) is a publication of the “Asociación Española de Pediatría” (AEP / Spanish Association of Pediatrics). Its contents are elaborated mainly by members of the Grupo de Trabajo de Pediatría Basada en la Evidencia (Evidence Based Pediatrics Working Group). This group is part of both, the AEP and the “Asociación Española de Pediatría de Atención Primaria” (Spanish Association of Primary Care Pediatrics / AEPap).
García-Alix A, Arnaez Solís J. Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón. Evid Pediatr. 2016;12:14.
Busl K, Greer D. Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. 2010;26:5-13.
Gunn AJ, Gunn TR, De Haan HH, Williams CE, Gluckman PD. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997;99:248-56.
Blanco D, Garcia-Alix A, Valverde E, Tenorio V, Vento M, Cabañas F, et al. Neuroprotección con hipotermia en el recién nacido con encefalopatía hipóxico-isquémica. Guía de estándares para su aplicación clínica. An Pediatr (Barc). 2011;75:341.e1-20.
Dinse A, Föhr KJ, Georgieff M, Beyer C, Bulling A, Weigt HU. Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones. Br J Anaesth. 2005;94:479-85.
Chakkarapani E, Dingley J, Liu X, Hoque N, Aquilina K, Porter H, Thoresen M. Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann Neurol. 2010;68:330-41.
Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, et al. Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol. 2011;70:133-50.
Sabir H, Walløe L, Dingley J, Smit E, Liu X, Thoresen M. Combined treatment of xenon and hypothermia in newborn rats–additive or synergistic effect? PLoS One. 2014;9:e109845.
Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. 2008;39:1307-13.
Dingley J, Tooley J, Liu X, Scull-Brown E, Elstad M, Chakkarapani E, et al. Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. 2014;133:809-18.
Ochoa C, González de Dios J. El xenón inhalado no parece mejorar el efecto de la hipotermia tras la asfixia perinatal. Evid Pediatr. 2016;12:4.
Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deleri A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016;15: 145-53.