March 2009. Volume 5. Number 1

An effective vaccine against malaria could be included in the childhood immunization schedule, without interfering with the immune response to other antigens

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Abdulla S, Oberholzer R, Juma O, Kubhoja S, Machera F, Membi C et al. Safety and immunogenicity of RTS, S/AS02D malaria vaccine in infants. N Engl J Med. 2008;359:2533-44
Reviewers: Orejón de Luna G1, Ramos Lizana J2.
1CS General Ricardos. Madrid. España.
2Unidad de Neurología Pediátrica. Hospital Torrecárdenas. Almería. España.
Correspondence: Gloria Orejón de Luna. Email: gloriaglo04@gmail.com
Reception date: 28/01/2009
Acceptance date: 30/01/2008
Publication date: 31/01/2009

Abstract

Authors' conclusions: the RTS,S/AS02D malaria vaccine seems to be safe in infants, it doesn’t interfere with immunological response to other co administered vaccines and diminishes the incidence of malaria infection.

Reviewers' comantary: implications for the practice: the RTS,S/AS02D vaccine seems to be the first effective vaccine against malaria infection in children. Implication for the investigation: phase 3 studies are needed to confirm the effectiveness, safety profile and inmunogenicity of the vaccine in order to include it in immunization schedules, especially in endemic areas and in populations at risk.

How to cite this article

Orejón de Luna G, Ramos Lizana J. Una vacuna eficaz frente a la malaria podría ser incluida en los calendarios vacunales infantiles, sin interferir con la respuesta inmunológica al resto de antígenos. Evid Pediatr 2009;5:7.

AVC | Critically appraised articles

Abdulla S, Oberholzer R, Juma O, Kubhoja S, Machera F, Membi C et al. Safety and immunogenicity of RTS, S/AS02D malaria vaccine in infants. N Engl J Med. 2008;359:2533-44
Reviewers: Orejón de Luna G1, Ramos Lizana J2.
1CS General Ricardos. Madrid. España.
2Unidad de Neurología Pediátrica. Hospital Torrecárdenas. Almería. España.
Correspondence: Gloria Orejón de Luna. Email: gloriaglo04@gmail.com
Reception date: 28/01/2009
Acceptance date: 30/01/2008
Publication date: 31/01/2009

How to cite this article

Orejón de Luna G, Ramos Lizana J. Una vacuna eficaz frente a la malaria podría ser incluida en los calendarios vacunales infantiles, sin interferir con la respuesta inmunológica al resto de antígenos. Evid Pediatr 2009;5:7.

References

  1. Kester KE, Cummings JF, Ockenhouse CF, Nielsen R, Hall BT, Gordon DM.et al. Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research. Vaccine. 2008;26:2191-202.
  2. Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Méd. 2008;359:2521-32.
  3. Sacarlal J, Aponte JJ, Aide P, Mandomando I, Bassat Q, Guinovart C et al. Safety of the RTS,S/AS02A malaria vaccina in Mozambique children during a Phase IIB trial. Vaccine. 2008;26:174-84.
  4. Aponte JJ, Aide P, Renom M, Mandomando I, Bassat Q, Sacarlal J et al. Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial. Lancet 2007;370:1543-51.
  5. Alonso PL, Sacarlal J, Aponte JJ, Leach A, Macete E, Milman J et al. Efficacy of the RTS,S/AS02A vaccine aganst Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet. 2004;364:1411-20.
31/01/2009

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