June 2009. Volume 5. Number 2

The conjugate pneumococcal vaccine has changed the etiology of pneumococcal meningitis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Hsu HE, Shutt KA, Moore MR, Beall BW, Bennett NM, Craig AS, et al. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N Engl J Med 2009;360:244-56
Reviewers: Pérez Gaxiola G1, Llerena Santa Cruz E2.
1Hospital Pediátrico de Sinaloa. Culiacán. México.
2Hospital Universitari Doctor Josep Trueta. Girona. España.
Correspondence: Giordano Pérez Gaxiola. Email: giordanoperez@hps.org.mx
Reception date: 15/04/2009
Acceptance date: 04/05/2009
Publication date: 01/06/2009

Abstract

Authors´ conclusions: rates of meningitis caused by the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) serotypes have decreased, but there is an increase in non-PCV7 serotypes.

Reviewers´ commentary: although it is an ecologic analysis and cases may have been missed, the study does show a decrease in meningitis caused by PCV7 serotypes and an increase in non-PCV7 serotypes, which invites to consider new prevention strategies

How to cite this article

Pérez Gaxiola G, Llerena Santa Cruz E. La vacuna conjugada contra el neumococo ha modificado la etiología de las meningitis neumocócicas. Evid Pediatr. 2009;5:39

AVC | Critically appraised articles

Hsu HE, Shutt KA, Moore MR, Beall BW, Bennett NM, Craig AS, et al. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N Engl J Med 2009;360:244-56
Reviewers: Pérez Gaxiola G1, Llerena Santa Cruz E2.
1Hospital Pediátrico de Sinaloa. Culiacán. México.
2Hospital Universitari Doctor Josep Trueta. Girona. España.
Correspondence: Giordano Pérez Gaxiola. Email: giordanoperez@hps.org.mx
Reception date: 15/04/2009
Acceptance date: 04/05/2009
Publication date: 01/06/2009

How to cite this article

Pérez Gaxiola G, Llerena Santa Cruz E. La vacuna conjugada contra el neumococo ha modificado la etiología de las meningitis neumocócicas. Evid Pediatr. 2009;5:39

References

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  2. Singleton RJ, Hennessy TW, Bulkow LR, Hanmit LL, Zulz T, Hurburt DA, et al. Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska Native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA. 2007;297:1784-92 .
  3. Byington CL, Korgenski K, Daly J, Ampofo K, Pavia A, Mason EO. Impact of the pneumococcal conjugate vaccine on pneumococcal parapneumonic empyema. Pediatr Infect Dis J. 2006;25:250-4.
  4. Ochoa Sangrador C, Castro Rodríguez JA. Los empiemas paraneumónicos neumocócicos han aumentado tras la introducción de la vacuna neumocócica conjugada heptavalente. Evid Pediatr. 2006;2:31.
  5. Lucero MG, Dulalia VE, Parreño RAN, Lim-Quianzon D, Nohynek H, Makela H et al. Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and pneumonia with consolidation on x-ray in children under two years of age. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004977.
01/06/2009

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