September 2009. Volume 5. Number 3

In children under 36 months the primary vaccination with one doses of attenuated influenza vaccine dose confers some protection against influenza

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Neto HB, Farhat CK, Tregnaghi MW, Madhi SA, Razmpour A, Palladino G et al. D153-P504 LAIV Study Group. Efficacy and safety of 1 and 2 doses of live attenuated influenza vaccine in vaccine-naive children. Pediatr Infect Dis. J. 2009;28:365-71
Reviewers: González Rodríguez MP1, Gimeno Díaz de Atauri Á2.
1CS Barrio del Pilar. Área 5. Madrid. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: María Paz González Rodríguez. Email: pazgonz@gmail.com
Reception date: 19/08/2009
Acceptance date: 27/08/2009
Publication date: 10/09/2009

Abstract

Authors´ conclusion: one dose of live attenuated influenza vaccine (LAIV) provided clinically significant protection against influenza in young children previously unvaccinated against influenza, 2 doses provided additional protection. Protection after 2 doses in year 1 persisted through a second season without revaccination. LAIV excipients were no a major contributor to reactogenicity.

Reviewers´ commentary: influenza vaccines are administered as a 2-dose schedule for previously unvaccinated children aged younger than 9 years. In this randomized controlled trial with a score of three over five in the Jadad Scale, the efficacy of one doses of live attenuated influenza vaccine (LAIV) is higher than placebo, although the efficacy of two doses is higher than one. LAIV was showed not efficacy in preventing otitis media. With the available data it would be advisable to follow the vaccination with two doses

How to cite this article

González Rodríguez MP, Gimeno Díaz de Atauri A. En menores de 36 meses la primovacunación con una dosis de vacuna gripal atenuada confiere cierta protección frente a la gripe. Evid Pediatr. 2009;5:68

AVC | Critically appraised articles

Neto HB, Farhat CK, Tregnaghi MW, Madhi SA, Razmpour A, Palladino G et al. D153-P504 LAIV Study Group. Efficacy and safety of 1 and 2 doses of live attenuated influenza vaccine in vaccine-naive children. Pediatr Infect Dis. J. 2009;28:365-71
Reviewers: González Rodríguez MP1, Gimeno Díaz de Atauri Á2.
1CS Barrio del Pilar. Área 5. Madrid. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: María Paz González Rodríguez. Email: pazgonz@gmail.com
Reception date: 19/08/2009
Acceptance date: 27/08/2009
Publication date: 10/09/2009

How to cite this article

González Rodríguez MP, Gimeno Díaz de Atauri A. En menores de 36 meses la primovacunación con una dosis de vacuna gripal atenuada confiere cierta protección frente a la gripe. Evid Pediatr. 2009;5:68

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10/09/2009

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