December 2009. Volume 5. Number 4

The current WHO standard regimen for retreatment of TB lacks evidence from clinical trials

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Menzies D, Benedetti A, Paydar A, Royce A, Pai M, et al. Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: A systematic review and meta-analysis. PLoS Med 6:e1000150. doi:10.1371/journal.pmed.100015
Reviewers: Pérez Gaxiola G1, Llerena Santa Cruz E2.
1Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
2Hospital Universitario Dr. Josep Trueta. Girona. España.
Correspondence: Giordano Pérez Gaxiola. Email: giordanopg@gmail.com
Reception date: 10/11/2009
Acceptance date: 20/11/2009
Publication date: 10/12/2009

Abstract

Authors' conclusions: there are few published studies to support use of the current TB standardized retreatment regimen. Randomized trials on the treatment of persons with isoniazid mono-resistance and/or a history of previous TB treatment are urgently needed.

Reviewers' commentary: there is not enough evidence to support the WHO standard regimen for retreatment of TBC. The analisis of the different current treatments shows a very variable efficacy. The management of previously treated or isoniazid resistant TB patients requires multinational clinical trials.

How to cite this article

Pérez Gaxiola G, Llerena Santa Cruz E. El actual régimen estandarizado de la OMS para el retratamiento de la tuberculosis carece de ensayos clínicos. Evid Pediatr. 2009;5:85.

AVC | Critically appraised articles

Menzies D, Benedetti A, Paydar A, Royce A, Pai M, et al. Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: A systematic review and meta-analysis. PLoS Med 6:e1000150. doi:10.1371/journal.pmed.100015
Reviewers: Pérez Gaxiola G1, Llerena Santa Cruz E2.
1Hospital Pediátrico de Sinaloa. Culiacán. Sinaloa. México.
2Hospital Universitario Dr. Josep Trueta. Girona. España.
Correspondence: Giordano Pérez Gaxiola. Email: giordanopg@gmail.com
Reception date: 10/11/2009
Acceptance date: 20/11/2009
Publication date: 10/12/2009

How to cite this article

Pérez Gaxiola G, Llerena Santa Cruz E. El actual régimen estandarizado de la OMS para el retratamiento de la tuberculosis carece de ensayos clínicos. Evid Pediatr. 2009;5:85.

References

  1. Organización Mundial de la Salud (2008) 108 p. Treatment of tuberculosis: guidelines for national programmes WHO/CDS/TB/2008 (revisado noviembre 2008).
  2. Jeffrey RS. New Concepts in childhood tuberculosis. Curr Opin Pediatr 19:306-13.
  3. Mellado Peña M.J., Baquero-Artigao F, Moreno-Perez D et al. Documento de consenso de la Sociedad Española de Infectología Pediátrica sobre la tuberculosis resistente a fármacos. An Pediatr (Barc). 2009;71:447-58.
10/12/2009

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