December 2010. Volume 6. Number 4

Heptavalent pneumococcal vaccine may reduce the incidence of admissions for pneumonia and empyema, although more and better studies are needed

 
 
 
 
 
 
 
 
 
 
Rating: 4 (1 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Koshy E, Murray J, Bottle A, Sharland M, Saxena S. Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008. Thorax. 2010;65:770-4.
Reviewers: Rivas Juesas C1, Gimeno Díaz de Atauri Á2.
1Servicio de Pediatría. Hospital de Sagunto. Valencia. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 19/10/2010
Acceptance date: 08/11/2010
Publication date: 18/11/2010

Abstract

Authors´ conclusion: childhood bacterial pneumonia and empyema admission rates were increasing prior to 2006 in England. They have observed a 19% and 22% decrease respectively between 2006 and 2008, following the introduction of the VCN7 pneumococcal conjugate vaccination to the national childhood immunisation programme.

Reviewers´ comentary: the study has methodological limitations, so the results should be interpreted with caution. Prospective studies, with proper microbiological confirmation and serotyping are needed to evaluate the vaccine efficacy in the prevention of pneumonia and parapneumonic effusion, as well as cost-effectiveness studies in areas with universal vaccination.

How to cite this article

Rivas Juesas C, Gimeno Díaz de Atauri A. La vacuna neumocócica heptavalente podría disminuir la incidencia de ingresos por neumonía y empiema, aunque hacen falta más estudios y mejores. Evid Pediatr. 2010;6:89.

AVC | Critically appraised articles

Koshy E, Murray J, Bottle A, Sharland M, Saxena S. Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008. Thorax. 2010;65:770-4.
Reviewers: Rivas Juesas C1, Gimeno Díaz de Atauri Á2.
1Servicio de Pediatría. Hospital de Sagunto. Valencia. España.
2Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
Correspondence: Cristina Rivas Juesas. Email: crisrijue@hotmail.com
Reception date: 19/10/2010
Acceptance date: 08/11/2010
Publication date: 18/11/2010

Structured Abstract

 

How to cite this article

Rivas Juesas C, Gimeno Díaz de Atauri A. La vacuna neumocócica heptavalente podría disminuir la incidencia de ingresos por neumonía y empiema, aunque hacen falta más estudios y mejores. Evid Pediatr. 2010;6:89.

References

  1. Pavia M, Bianco A, Nobile CG, Marinelli P, Angelillo IF. Efficacy of Pneumococcal Vaccination in Children Younger than 24 months: A Meta- Analysis. Pediatrics. 2009;123:e1103-10.
  2. Byington CL, Korgenski K, Daly J, Ampofo K, Pavia A, Mason EO. Impact of pneumococcal conjugate vaccine on pneumococcal parapneumonic empyema. Pediatr Infect Dis J. 2006;25:250-4.
  3. Fenoll A, Granizo JJ, Aguilar L, Giménez MJ, Aragoneses-Fenoll L, Hanquet G, et al. Temporal trends of invasive Streptococcus pneumoniae serotypes and antimicrobial resistance patterns in Spain from 1979 to 2007. J Clin Microbiol. 2009;47:1012-20.
  4. Grijalva CG, Nuorti JP, Arbogast PG, Martin SW, Edwards KM, Griffin MR. Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet. 2007;369:1179-86.
  5. Ochoa Sangrador C, Andrés de Llano J. Una vacuna neumocócica conjugada 11-valente no reduce significativamente las neumonías adquiridas en la comunidad con diagnóstico radiológico en niños menores de dos años. Evid Pediatr. 2009;5:63.
  6. Sinha A, Levine O, Knoll MD, Muhib F, Lieu TA. Cost-effectiveness of pneumococcal conjugate vaccination in the prevention of child mortality: an international economic analysis. Lancet. 2007;369:389-96.
18/11/2010

Linked Comment