September 2011. Volume 7. Number 3

Corticosteroids administered during pregnancy did not appear to be associated with increased risk of orofacial clefts

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183:796-804.
Reviewers: Llerena Santa Cruz E1, Guarch Ibáñez B2, Buñuel Álvarez JC3.
1Hospital Universitario Dr. Josep Trueta. Girona. España.
2Hospital Universitario Dr. Josep Trueta. Girona. España.
3Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 16/07/2011
Acceptance date: 19/07/2011
Publication date: 27/07/2011

Abstract

Authors' conclusion: there does not seem to bean increased risk of orofacial clefts associated with the use of corticosteroids during pregnancy. The association between cleft lip with / without cleft palate and dermatological use of corticosteroids during pregnancy may be due to chance, as the result of multiple statistical comparisons, without implying a causal relationship.

Reviewers' commentary: the resultsof this study may permit the use of steroids in those pregnant women, in whom the treatment of certain diseases makes absolutely essential their use. The presence of other potential adverse effects of corticosteroids during pregnancy (e.g. fetal growth retardation, low birth weight) recommends extreme caution with the use of these drugs.

How to cite this article

Llerena Santa Cruz E, Guarch Ibáñez B, Buñuel Álvarez JC. Los corticoides administrados durante la gestación no parecen asociarse a mayor riesgo de hendiduras orofaciales. Evid Pediatr. 2011;7:63.

AVC | Critically appraised articles

Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183:796-804.
Reviewers: Llerena Santa Cruz E1, Guarch Ibáñez B2, Buñuel Álvarez JC3.
1Hospital Universitario Dr. Josep Trueta. Girona. España.
2Hospital Universitario Dr. Josep Trueta. Girona. España.
3Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 16/07/2011
Acceptance date: 19/07/2011
Publication date: 27/07/2011

How to cite this article

Llerena Santa Cruz E, Guarch Ibáñez B, Buñuel Álvarez JC. Los corticoides administrados durante la gestación no parecen asociarse a mayor riesgo de hendiduras orofaciales. Evid Pediatr. 2011;7:63.

References

  1. Edwards MJ, Agho K, Attia J, Diaz P, Hayes T, Illingworth A et al. Case-control study of cleft lip or palate after maternal use of topical corticosteroids during pregnancy. Am J Med Genet A. 2003;120A(4):459-63.
  2. Källén B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol. 1999;93:392-5.
  3. Chi CC, Mayon-White RT, Wojnarowska FT. Safety of topical corticosteroids in pregnancy: a population-based cohort study. J Invest Dermatol. 2011;131:884-91.
  4. Chi CC, Lee CW, Wojnarowska F, Kirtschig G. Safety of topical corticosteroids in pregnancy. Cochrane Database of Systematic Reviews. 2009, Issue 3. Art. No.: CD007346. DOI: 10.1002/14651858.CD007346.pub2.
  5. Källén B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol. 1999;93:392-5.
27/07/2011

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