September 2011. Volume 7. Number 3

Ibuprofen and patent ductus arteriosus of preterm: intravenous or oral?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Gokmen T, Erdeve O, Altug N, Suna Oguz S, Uras N, Dilmen UJ. Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus. J Pediatr. 2011;158:549-54.
Reviewers: González de Dios J1, Rivas Fernández MÁ2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Hospital General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 21/07/2011
Acceptance date: 22/07/2011
Publication date: 27/07/2011

Abstract

Authors' conclusions: oral ibuprofen is more effective than intravenous ibuprofen for the closure of patent ductus arteriosus in premature newborns with very low birth weight. Patients with boderline renal function should be closely monitored.

Reviewers' commentary: this clinical trial makes plausible to implement the use of oral ibuprofen for the closure of patent ductus arteriosus in premature newborns, what is a great improvement in the cost-effectiveness. We need more clinical trials that replicate these results to recommend oral ibuprofen as an effective and safe intervention.

How to cite this article

González de Dios J, Rivas Fernández MA. Ibuprofeno y conducto arterial persistente del prematuro: ¿vía intravenosa o vía oral? Evid Pediatr. 2011;7:64.

AVC | Critically appraised articles

Gokmen T, Erdeve O, Altug N, Suna Oguz S, Uras N, Dilmen UJ. Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus. J Pediatr. 2011;158:549-54.
Reviewers: González de Dios J1, Rivas Fernández MÁ2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Hospital General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 21/07/2011
Acceptance date: 22/07/2011
Publication date: 27/07/2011

How to cite this article

González de Dios J, Rivas Fernández MA. Ibuprofeno y conducto arterial persistente del prematuro: ¿vía intravenosa o vía oral? Evid Pediatr. 2011;7:64.

References

  1. De Armas Iglesias I, González de Dios J, Aparicio Sánchez JL. Indometacina e ibuprofeno en el tratamiento del conducto arterial persistente del prematuro: la duda no es la eficacia, sino la seguridad. Evid Pediatr. 2011;7:45.
  2. Erdeve O, Gokmen T. Oral versus intravenous iIbuprofen: which is better in closure of patent ductus arteriosus? Pediatrics. 2009;123:e763.
  3. Cherif A, Khrouf N, Jabnoun S, Mokrani C, Amara MB, Guellouze N et al. Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus. Pediatrics. 2008;122:e1256-61.
  4. Sharma PK, Garg SK, Narang A. Pharmacokinetics of oral ibuprofen in premature infants. J Clin Pharmacol. 2003;43:968-73.

27/07/2011

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