March 2012. Volume 8. Number 1

Therapy with intravenous immune-globulins doesn’t seem to have any effect on the outcomes of suspected or proven neonatal sepsis in preterm newborns

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

INIS Collaborative Group. Treatment of Neonatal Sepsis with Intravenous Immune Globulin. N Engl J Med. 2011;365:1201-11
Reviewers: Molina Arias M1, Aparicio Sánchez JL2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
Correspondence: Manuel Molina Arias. Email: mmolina.hulp@salud.madrid.org
Reception date: 09/11/2011
Acceptance date: 19/12/2011
Publication date: 21/12/2011

Abstract

Author’s conclusion: therapy with intravenous immune-globulins had no effect on the outcomes of suspected or proven neonatal sepsis in preterm newborns.

Reviewer’s commentary: the results of this trial don’t support the routine administration of immune-globulins to decrease mortality or prevent major disabilities in preterm newborns with suspected or proven neonatal sepsis.

How to cite this article

Molina Arias M, Aparicio Sánchez JL. La gammaglobulina intravenosa no parece modificar el pronóstico de la sepsis neonatal sospechada o confirmada en prematuros. Evid Pediatr. 2012;8:6.

AVC | Critically appraised articles

INIS Collaborative Group. Treatment of Neonatal Sepsis with Intravenous Immune Globulin. N Engl J Med. 2011;365:1201-11
Reviewers: Molina Arias M1, Aparicio Sánchez JL2.
1Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
2Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
Correspondence: Manuel Molina Arias. Email: mmolina.hulp@salud.madrid.org
Reception date: 09/11/2011
Acceptance date: 19/12/2011
Publication date: 21/12/2011

How to cite this article

Molina Arias M, Aparicio Sánchez JL. La gammaglobulina intravenosa no parece modificar el pronóstico de la sepsis neonatal sospechada o confirmada en prematuros. Evid Pediatr. 2012;8:6.

References

  1. Lawn JE, Cousens S, Zupan J, 4 Million neonatal deaths: When? Where? Why? Lancet. 2005;365:891-900.
  2. Salimonu LS, Ladipo OA, Adeniran SO, Osukoya BO. Serum immunoglobulin levels in normal, premature and postmature newborns and their mothers. Int J Gynaecol Obstet. 1978:16:119-23.
  3. Ohlsson A, Lacy J. Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst Rev. 2010:17:CD001239.
21/12/2011

Linked Comment