September 2013. Volume 9. Number 3

The H1N1 vaccine is safe and effective during pregnancy and may decrease the risk of fetal mortality.

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Håberg SE, Trogstad L, Gunnes N, Wilcox AJ, Gjessing HK, Samuelsen SO, et al. Risk of fetal death afterpandemic influenza virus infection or vaccination. N Engl J Med. 2013;368(4):333-40.
Reviewers: Llerena Santa Cruz E1, Guarch Ibáñez B2, Murga Cabero S3.
1Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. Girona. España.
2Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. España.
3Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 07/07/2013
Acceptance date: 22/07/2013
Publication date: 31/07/2013

Abstract

Authors' conclusion: pandemic influenza virus infection in pregnancy was associated to an increased risk of fetal death. Vaccination Turing pregnancy reduced the risk of an influenza diagnosis. Vaccination its elf was not associated to increased fetal mortality and may have reduced the risk of influenza-related fetal death during the pandemic.

Reviewers' commentary: the vaccine against H1N1 influenza virus is safe during the second and third trimester of pregnancy. This study has the largest sample to date to evaluate this vaccine. The risk of fetal death during pregnancy was not statistically significant.

How to cite this article

Llerena Santa Cruz E, Guarch Ibáñez B, Murga Cabero S. La vacuna H1N1 es segura y efectiva durante el embarazo y puede disminuir el riego de mortalidad fetal. EvidPediatr.2013;9:49.

AVC | Critically appraised articles

Håberg SE, Trogstad L, Gunnes N, Wilcox AJ, Gjessing HK, Samuelsen SO, et al. Risk of fetal death afterpandemic influenza virus infection or vaccination. N Engl J Med. 2013;368(4):333-40.
Reviewers: Llerena Santa Cruz E1, Guarch Ibáñez B2, Murga Cabero S3.
1Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. Girona. España.
2Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. España.
3Servicio de Pediatría. Hospital Universitario Dr. Josep Trueta. Girona. España.
Correspondence: Enrique Llerena Santa Cruz. Email: santum7@yahoo.com
Reception date: 07/07/2013
Acceptance date: 22/07/2013
Publication date: 31/07/2013

How to cite this article

Llerena Santa Cruz E, Guarch Ibáñez B, Murga Cabero S. La vacuna H1N1 es segura y efectiva durante el embarazo y puede disminuir el riego de mortalidad fetal. EvidPediatr.2013;9:49.

References

  1. Munoz FM. Safety of influenza vaccines in pregnant women. Am J Obstet Gynecol. 2012;207(3 Suppl):S33-7.
  2. Pasternak B, Svanström H, Mølgaard-Nielsen D, Krause TG, Emborg HD, Melbye M, et al. Risk of adverse fetal outcomes following administration of a pandemic influenza A(H1N1) vaccine during pregnancy. JAMA. 2012;308:165-74.
  3. Chavant F, Ingrand I, Jonville-Bera AP, Plazanet C, Gras-Champel V, Lagarce L, et al. The PREGVAXGRIP Study: a Cohort Study to Assess Foetal and Neonatal Consequences of In Utero Exposure to Vaccination Against A(H1N1)v2009 Influenza. Drug Saf. 2013;36:455-65.
  4. Adegbola R, Nesin M, Wairagkar N. Immunogenicity and efficacy of influenza immunization during pregnancy: recent and ongoing studies. Am J Obstet Gynecol. 2012;207(3 Suppl):S28-32.
31/07/2013

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