March 2014. Volume 10. Number 1

There is no increase in the overall risk of cancer among children born after assisted conception

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Williams CL, Bunch KJ, Stiller CA, Murphy MF, Botting BJ, Wallace WH, et al. Cancer risk among children born after assisted conception. N Engl J Med. 2013;369:1819-27.
Reviewers: de Lucas García N1, Martín Muñoz P2.
1SAMUR-Protección Civil. Madrid. España.
2Director de Unidad Clínica en Atención Primaria, CS La Plata. Hospital Universitario Virgen del Rocí­o. Sevilla. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 19/02/2014
Acceptance date: 23/02/2014
Publication date: 05/03/2014

Abstract

Authors’ conclusions: increased risk of cancer is not observed among British children born after assisted reproduction during the 17 year follow-up. Although an absolute risk increase for hepatoblastoma and rhabdomyosarcoma was detected, it was small.

Reviewers’ commentary: according to these results there is no increase in the total number of cancers in children born after assisted reproduction, although it still persists the question of whether a high index of suspicion for the accompanying symptoms of hepatoblastoma and rhabdomyosarcoma is needed. It would be necessary to study larger cohorts to clarify the existence of this association.

How to cite this article

de Lucas García N, Martin Muñoz P. Los niños nacidos tras reproducción asistida no presentan más riesgo de cáncer. Evid Pediatr. 2014;10:2.

AVC | Critically appraised articles

Williams CL, Bunch KJ, Stiller CA, Murphy MF, Botting BJ, Wallace WH, et al. Cancer risk among children born after assisted conception. N Engl J Med. 2013;369:1819-27.
Reviewers: de Lucas García N1, Martín Muñoz P2.
1SAMUR-Protección Civil. Madrid. España.
2Director de Unidad Clínica en Atención Primaria, CS La Plata. Hospital Universitario Virgen del Rocí­o. Sevilla. España.
Correspondence: Nieves de Lucas García. Email: delucasn@gmail.com
Reception date: 19/02/2014
Acceptance date: 23/02/2014
Publication date: 05/03/2014

How to cite this article

de Lucas García N, Martin Muñoz P. Los niños nacidos tras reproducción asistida no presentan más riesgo de cáncer. Evid Pediatr. 2014;10:2.

References

  1. Williams C, Constantine A, Sutcliffe A. Systematic review and meta-analysis of cancer risk in children born after assisted reproduction. Arch Dis Child. 2011;96:A6.
  2. Källén B, Finnström O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Cancer RIEk in children and young adults conceived by in vitro fertilization. Pediatrics. 2010;126:270-6.

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Plaza López de Sabando D. ¿Incrementa la reproducción asistida el riesgo de cáncer pediátrico? Evid Pediatr. 2014;10:1.
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