July 2014. Volume 10. Number 2

Probiotics, prematurity and sepsis: when a negative result may be positive

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Jacobs SE, Tobin JM, Opie GF, Donath S, Tabrizi SN, Pirotta M, et al. ProPrems Study Group. Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial. Pediatrics. 2013;132:1055-62.

Reviewers: González de Dios J1, González Muñoz M2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Faculta de Medicina y Odontología. Valencia. Valencia. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 28/01/2014
Acceptance date: 03/02/2014
Publication date: 02/04/2014

Abstract

Authors’ conclusions: this combination of probiotics significantly reduced NEC of Bell stage ≥2 in very preterm infants, but not late-onset sepsis or mortality.

Reviewers’ commentary: this clinical trial did not confirmed that probiotics reduce late sepsis in very preterm infants, but we can say that probiotics do not increase the incidence of sepsis. So, this study supports that probiotic supplementation of enteral feeding in very preterm infants presents a favorable balance of benefits (less severe necrotizing enterocolitis and/or mortality), risks (safe even for the potential risk of infection) and costs.

How to cite this article

González de Dios J, González Muñoz M. Probióticos, prematuridad y sepsis: cuando un resultado negativo puede ser positivo. Evid Pediatr. 2014;10:25.

AVC | Critically appraised articles

Jacobs SE, Tobin JM, Opie GF, Donath S, Tabrizi SN, Pirotta M, et al. ProPrems Study Group. Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial. Pediatrics. 2013;132:1055-62.

Reviewers: González de Dios J1, González Muñoz M2.
1Departamento de Pediatría. Hospital General Universitario de Alicante. España.
2Faculta de Medicina y Odontología. Valencia. Valencia. España.
Correspondence: Javier González de Dios. Email: javier.gonzalezdedios@gmail.com
Reception date: 28/01/2014
Acceptance date: 03/02/2014
Publication date: 02/04/2014

How to cite this article

González de Dios J, González Muñoz M. Probióticos, prematuridad y sepsis: cuando un resultado negativo puede ser positivo. Evid Pediatr. 2014;10:25.

References

  1. Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sánchez PJ, et al; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123:58-66.
  2. González de Dios J, González Muñoz M. Probióticos y enterocolitis necrotizante del prematuro: to NEC or not to NEC?, ésta es la pregunta. Nutr Hosp. 2013;28:2115-23.
02/04/2014

¿Hay o no menos mortalidad?

02 de April de 2014 Luis Miguel Fernández Cuesta
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