December 2015. Volume 11. Number 4

First clinical trial about therapeutic hypothermia after out-of-hospital cardiac arrest in children

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, et al. THAPCA trial investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372:1898-908.
Reviewers: Pérez-Moneo Agapito B1, Rivas Fernández MÁ2.
1Hospital Universitario Infanta Leonor. Madrid. España.
2Hospital General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: Begoña Pérez-Moneo Agapito. Email: begopma@gmail.com
Reception date: 14/10/2015
Acceptance date: 22/10/2015
Publication date: 04/11/2015

Abstract

Authors' conclusions: therapeutic hypothermia in comatose children who survived an out-of-hospital cardiac arrest – compared with normothermia – didn´t confer a significant benefit in terms of survival with good neurological outcome at 12 months.

Reviewers' commentary:there were no statistic differences between therapeutic hypothermia or normothermia in any outcome, but it's clinically relevant that 1 of 13 patients in the hypothermia group has a positive outcome, without any of the adverse effects seen in the other 12. There are issues for future research, as if active control of fever could be the principal protector factor, or if hypothermia should be administered in some other way (with cool caps as in newborns, for example).

How to cite this article

Pérez-Moneo Agapito B, Rivas Fernández MA. Primer ensayo clínico en niños sobre la hipotermia como tratamiento de la parada cardiaca extrahospitalaria. Evid Pediatr. 2015;11:63.

AVC | Critically appraised articles

Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, et al. THAPCA trial investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372:1898-908.
Reviewers: Pérez-Moneo Agapito B1, Rivas Fernández MÁ2.
1Hospital Universitario Infanta Leonor. Madrid. España.
2Hospital General de Cataluña. Sant Cugat del Vallés. Barcelona. España.
Correspondence: Begoña Pérez-Moneo Agapito. Email: begopma@gmail.com
Reception date: 14/10/2015
Acceptance date: 22/10/2015
Publication date: 04/11/2015

How to cite this article

Pérez-Moneo Agapito B, Rivas Fernández MA. Primer ensayo clínico en niños sobre la hipotermia como tratamiento de la parada cardiaca extrahospitalaria. Evid Pediatr. 2015;11:63.

References

  1. The hypothermia after cardiac arrest study group. Mild therapeutic hypothermia to improve the neurological outcome after cardiac arrest. N Engl J Med. 2002;346:557.
  2. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008;358:2447.
  3. Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371:140.
  4. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med. 2013;369:2197.
  5. Dietrich WD, Bramlett HM. Hyperthermia and central nervous system injury. Prog Brain Res. 2007;162:201-17.
04/11/2015

Linked Comment