December 2023. Volume 19. Number 4

Meningococcal group B vaccine is effective in preventing cases of meningococcal B group sepsis and meningitis

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Castilla J, García Cenoz M, Abad R, Sánchez-Cambronero l, Lorusso N, Izquierdo C, et al. Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children. N Engl J Med 2023;388:427-38.

Reviewers: Perdikidis Olivieri L1, Lemos Bouzas MX2.
1Pediatra. EAP Juncal. Torrejón de Ardoz. Madrid. España.
2CS San Roque. Vilagarcía de Arousa. Pontevedra. España.
Correspondence: Leo Perdikidis Olivieri. Email: lperdikidis@gmail.com
Reception date: 04/09/2023
Acceptance date: 28/09/2023
Publication date: 08/11/2023

Abstract

Authors´ conclusions: complete vaccination with 4CMenB was shown to be effective in preventing invasive disease due to serogroup B and non–serogroup B meningococci in Spanish children younger than 5 years of age. This evidence may be useful for the inclusion of this vaccine in the immunization program of countries where invasive meningococcal disease in children is problematic and its prevention a priority.

Reviewers´ commentary: this is a well-designed study that collects all cases of meningococcal B infection compared with matched controls (4 per case). The authors have minimized the risk of bias by controlling confounding factors and effect modifiers and conclude on its good efficacy.

How to cite this article

Perdikidis Olivieri L, Lemos Bouzas MX. La vacuna frente a meningoco B es eficaz para prevenir casos de sepsis y meningitis. Evid Pediatr. 2023;19:43.

AVC | Critically appraised articles

Castilla J, García Cenoz M, Abad R, Sánchez-Cambronero l, Lorusso N, Izquierdo C, et al. Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children. N Engl J Med 2023;388:427-38.

Reviewers: Perdikidis Olivieri L1, Lemos Bouzas MX2.
1Pediatra. EAP Juncal. Torrejón de Ardoz. Madrid. España.
2CS San Roque. Vilagarcía de Arousa. Pontevedra. España.
Correspondence: Leo Perdikidis Olivieri. Email: lperdikidis@gmail.com
Reception date: 04/09/2023
Acceptance date: 28/09/2023
Publication date: 08/11/2023

How to cite this article

Perdikidis Olivieri L, Lemos Bouzas MX. La vacuna frente a meningoco B es eficaz para prevenir casos de sepsis y meningitis. Evid Pediatr. 2023;19:43.

08/11/2023

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