March 2025. Volume 21. Number 1

Intranasal fentanyl in pediatric emergencies: is it safe and effective?

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Alsabri M, Hafez AH, Singer E, Elhady MM, Waqar M, Gill P. Efficacy and Safety of Intranasal Fentanyl in Pediatric Emergencies: A Systematic Review and Meta-analysis. Pediatr Emerg Care. 2024;40:748-52.

Reviewers: Flores Villar S1, Fraile Astorga G2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Pediatra. CS Cuellar. Segovia. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 10/01/2025
Acceptance date: 19/01/2025
Publication date: 29/01/2025

Abstract

Authors´ conclusions: intranasal fentanyl (INF) is more effective in reducing pain than other analgesics at the 15- to 20-minute point. However, no significant differences were observed at the 30- and 60-minute time points. In addition, INF exhibited a better adverse outcome profile with a lower risk of nausea and vomiting than other analgesics, although there were no significant differences regarding dizziness and hallucinations.

Reviewers´ commentary: the use of INF is an additional tool on the therapeutic arsenal for cases with moderate or severe pain and difficult venous access. In this meta-analysis, due to methodological limitations, it cannot be concluded that INF is the treatment of choice, as the comparators used are different. Furthermore, regarding side effects, the conclusions cannot be considered valid for the same reason. Observational studies with longer follow-up would be necessary to reach the conclusions specified in this meta-analysis.

How to cite this article

Flores Villar S, Fraile Astorga G. Fentanilo intranasal en urgencias pediátricas: ¿es seguro y eficaz? Evid Pediatr. 2025;21:5.

AVC | Critically appraised articles

Alsabri M, Hafez AH, Singer E, Elhady MM, Waqar M, Gill P. Efficacy and Safety of Intranasal Fentanyl in Pediatric Emergencies: A Systematic Review and Meta-analysis. Pediatr Emerg Care. 2024;40:748-52.

Reviewers: Flores Villar S1, Fraile Astorga G2.
1Pediatra. Área de Hospitalización Pediátrica. Hospital Universitario MútuaTerrassa. Barcelona. España.
2Pediatra. CS Cuellar. Segovia. España.
Correspondence: Sergio Flores Villar. Email: sflores@mutuaterrassa.es
Reception date: 10/01/2025
Acceptance date: 19/01/2025
Publication date: 29/01/2025

How to cite this article

Flores Villar S, Fraile Astorga G. Fentanilo intranasal en urgencias pediátricas: ¿es seguro y eficaz? Evid Pediatr. 2025;21:5.

29/01/2025

Linked Comment