December 2025. Volume 21. Number 4

A birth dose of acellular pertussis vaccine does not impair antibody responses to booster doses of pertussis vaccines

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

McAlister SM, Van den Biggelaar AHJ, Cooper MN, Thornton R, Richmond P, Marshall H et al. Acellular pertussis vaccine given in the week after birth does not impair antibody responses to later childhood doses. Pediatr Infect Dis J. 2025;44:476-83.

Reviewers: Espínola Docio B1, González Rodríguez MP2.
1Pediatra. CS Los Alperchines. San Fernando de Henares. Madrid. España.
2Pediatra. CS Barrio del Pilar. Madrid. España.
Correspondence: Blanca Espínola Docio. Email: blaespdo@gmail.com
Reception date: 24/10/2025
Acceptance date: 05/11/2025
Publication date: 12/11/2025

Abstract

Authors´ conclusions: a birth dose of acellular pertussis vaccine does not impair antibody responses to booster doses of pertussis vaccines and may be an alternative for protection against early infant pertussis when pertussis booster has not been administered during pregnancy.

Reviewers´ commentary: this is a methodologically sound study that has clinical relevance and applicability in our setting. However, its results are unlikely to change current vaccination recommendations given the moderate magnitude of the effects found and the high cost of the measure.

How to cite this article

Espínola Docio B, González P. Una dosis de vacuna acelular de tosferina al nacimiento no interfiere con la respuesta inmunológica en las dosis posteriores de vacuna. Evid Pediatr. 2025;21:45.

AVC | Critically appraised articles

McAlister SM, Van den Biggelaar AHJ, Cooper MN, Thornton R, Richmond P, Marshall H et al. Acellular pertussis vaccine given in the week after birth does not impair antibody responses to later childhood doses. Pediatr Infect Dis J. 2025;44:476-83.

Reviewers: Espínola Docio B1, González Rodríguez MP2.
1Pediatra. CS Los Alperchines. San Fernando de Henares. Madrid. España.
2Pediatra. CS Barrio del Pilar. Madrid. España.
Correspondence: Blanca Espínola Docio. Email: blaespdo@gmail.com
Reception date: 24/10/2025
Acceptance date: 05/11/2025
Publication date: 12/11/2025

How to cite this article

Espínola Docio B, González P. Una dosis de vacuna acelular de tosferina al nacimiento no interfiere con la respuesta inmunológica en las dosis posteriores de vacuna. Evid Pediatr. 2025;21:45.

12/11/2025

Linked Comment

Methodological note