June 2006. Volume 2. Number 2

A novel vaccine that contained polysaccharides from 11 different Streptococcus pneumoniae serotypes each conjugated to Haemophilus influenzae-derived protein produced little decrease of acute otitis media, with a selected diagnosis, during the first two years of life

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Prymula R, Peeters P, Chorobok V, Kriz P, Novakova E, Kaliskova E, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet. 2006;367:740-8
Reviewers: Ochoa Sangrador C1, Orejón de Luna G2.
1Servicio de Pediatrí­a. Hospital Virgen de la Concha. Zamora. España.
2CS General Ricardos. Madrid. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: 10/05/2006
Acceptance date: 22/05/2006
Publication date: 01/06/2006

Abstract

How to cite this article

Orejón de Luna G, Ochoa Sangrador C. Una nueva vacuna frente a 11 serotipos de Streptococcus pneumoniae, conjugada con una proteína de Haemophilus influenzae, reduce escasamente las otitis, diagnosticadas de forma restringida, en los dos primeros años de vida. Evid Pediatr. 2006;2:28.

AVC | Critically appraised articles

Prymula R, Peeters P, Chorobok V, Kriz P, Novakova E, Kaliskova E, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet. 2006;367:740-8
Reviewers: Ochoa Sangrador C1, Orejón de Luna G2.
1Servicio de Pediatrí­a. Hospital Virgen de la Concha. Zamora. España.
2CS General Ricardos. Madrid. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: 10/05/2006
Acceptance date: 22/05/2006
Publication date: 01/06/2006

How to cite this article

Orejón de Luna G, Ochoa Sangrador C. Una nueva vacuna frente a 11 serotipos de Streptococcus pneumoniae, conjugada con una proteína de Haemophilus influenzae, reduce escasamente las otitis, diagnosticadas de forma restringida, en los dos primeros años de vida. Evid Pediatr. 2006;2:28.

References

  1. Eskola J, Kilpi T, Palmu A, Jokinen J, Haapakoski J, Herva E, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med. 2001;344:403-9.
  2. Fireman B, Black SB, Shinefield HR, Lee J, Lewis E, Ray P. Impact of the pneumococcal conjugate vaccine on otitis media. Pediatr Infect Dis J. 2003;22:10-6.
  3. Brouwer C, Maillé R, Rovers M, Veenhoven R, Grobee D, Sanders E, Schilder A. Effect of pneumococcal vaccination on quality of life in children with recurrent acute otitis media: a randomized, controlled trial. Pediatrics. 2005;115:273-9.
01/06/2006

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