The use of salmeterol plus inhaled corticosteroids does not appear to increase the incidence of severe asthma related events" />

December 2008. Volume 4. Number 4

The use of salmeterol plus inhaled corticosteroids does not appear to increase the incidence of severe asthma related events

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Bateman E, Nelson H, Bousquet J, Kral K, Sutton L, Ortega H, Yancey S. Meta-analysis: Effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events. Ann Intern Med. 2008;149:33-42
Reviewers: Gimeno Díaz de Atauri Á1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2CS Barrio del Pilar. Área 5. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: //28
Acceptance date: 05/11/2008
Publication date: 01/12/2008

Abstract

Authors' conclusions: salmeterol combined with inhaled corticosteroids decreases the risk for severe exacerbations, does not seem to alter the risk for asthma-related hospitalizations, and may not alter the risk for asthma-related deaths or intubations compared with inhaled corticosteroids alone.

Reviewers' comantary: long acting beta-agonists (LABA) are recommended by clinical guidelines in association with inhaled corticosteroids as a third step for management of asthma. An increased risk of life-threatening and fatal asthma attacks has been described in relation with its use. In this study, despite their methodological limitations, no increase in the morbidity or mortality related to asthma has been found in people treated with LABA and inhaled corticosteroids. There are studies in course comparing the adverse events in asthmatic patients in treatment with salmeterol and inhaled corticosteroids versus patients only treated with inhaled corticosteroids. There will be interesting to provide information about the real relationship between the salmeterol and asthma-related serious adverse events.

How to cite this article

Gimeno Díaz de Atauri A, González Rodríguez MP. La utilización de salmeterol asociada a corticoides inhalados no parece aumentar la incidencia de episodios graves relacionados con el asma. Evid Pediatr. 2008;4:82.

AVC | Critically appraised articles

Bateman E, Nelson H, Bousquet J, Kral K, Sutton L, Ortega H, Yancey S. Meta-analysis: Effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events. Ann Intern Med. 2008;149:33-42
Reviewers: Gimeno Díaz de Atauri Á1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2CS Barrio del Pilar. Área 5. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: //28
Acceptance date: 05/11/2008
Publication date: 01/12/2008

How to cite this article

Gimeno Díaz de Atauri A, González Rodríguez MP. La utilización de salmeterol asociada a corticoides inhalados no parece aumentar la incidencia de episodios graves relacionados con el asma. Evid Pediatr. 2008;4:82.

References

  1. O’Byrne P, Bateman ED, Bousquet J, Clark T, Ohta K, Paggiaro P, et al. Global strategy for asthma management and prevention, Global Initiative for Asthma (GINA) 2007.
  2. Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM. The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006;129:15-26.
  3. Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med. 2006;144:904-12.
  4. Ni Chroinin M, Greenstone IR, Danish A, Magdolinos H, Masse V, Zhang X et al. Agonistas beta2 de acción prolongada versus placebo además de corticosteroides inhalados para niños y adultos con asma crónica (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, número 3, 2008. Oxford, Update Software Ltd. Disponible en: http://www.update-software.com. (Traducida de The Cochrane Library, Issue. Chichester, UK: John Wiley & Sons, Ltd.)
  5. Cates CJ, Cates MJ. Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events. The Cochrane Database of Syst Rev. 2008;16:CD006363
  6. Jaeschke R, O'Byrne PM, Mejza F, Nair P, Lesniak W, Brozek J et al. The safety of long acting beta agonists among patients with asthma using Inhaled corticosteroids. Am J Respir Crit Care Med. 2008;178:1009-16.
01/12/2008

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