June 2009. Volume 5. Number 2

In allergic rhinoconjunctivitis in children the therapy with five-grass-pollen sublingual immunotherapy tablets provides a small benefit

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wahn U, Tabar A, Kuna P, Halken S, Montagut A, de Beaumont O, et al; SLIT Study Group. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2009;123:160-6
Reviewers: Gimeno Díaz de Atauri Á1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2CS Barrio del Pilar. Área 5. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 3/04/2009
Acceptance date: 10/04/2009
Publication date: 22/04/2009

Abstract

Authors' conclusions: Five-grass-pollen sublingual immunotherapy (SLIT) tablets (300 IR) reduce both symptom scores and rescue medication use in children and adolescentes with grass pollen-related rhinoconjunctivitis.

Reviewers' commentary: Sublingual immunotherapy is a therapeutic option in allergic rhinoconjunctivitis for adults and children. In this study the efficacy and security of a tablet presentation is evaluated. Small benefit in symptoms and need for rescue medication is demonstrated compared with placebo. These results have been published in previous systematic reviews. More studies are needed to asses the utilization of this treatment.

How to cite this article

Gimeno Díaz de Atauri A, González Rodríguez MP. En niños con rinoconjuntivitis estacional, una vacuna sublingual en comprimidos para gramíneas tiene una eficacia limitada. Evid Pediatr. 2009;5:36.

AVC | Critically appraised articles

Wahn U, Tabar A, Kuna P, Halken S, Montagut A, de Beaumont O, et al; SLIT Study Group. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2009;123:160-6
Reviewers: Gimeno Díaz de Atauri Á1, González Rodríguez MP2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2CS Barrio del Pilar. Área 5. Madrid. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 3/04/2009
Acceptance date: 10/04/2009
Publication date: 22/04/2009

How to cite this article

Gimeno Díaz de Atauri A, González Rodríguez MP. En niños con rinoconjuntivitis estacional, una vacuna sublingual en comprimidos para gramíneas tiene una eficacia limitada. Evid Pediatr. 2009;5:36.

References

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  2. Wilson DR, Lima MT, Durham SR. Sublingual immmunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60:4-12.
  3. Rivas Juesas C, González de Dios J. La inmunoterapia sublingual demuestra ser eficaz en los niños con asma alérgico. Evid Pediatr. 2008;4:28.
  4. Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W et al. Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. J Allergy Clin Immunol. 2008;121:512-8.
  5. Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Inmunoterapia con inyección de alérgenos para la rinitis alérgica estacional (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford.
  6. Röder E, Berger MY, de Groot H, van Wijk RG. Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review. Pediatr Allergy Immunol. 2008;19:197-207.
22/04/2009

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