December 2010. Volume 6. Number 4

Industry funded trials are more likely to find favorable outcomes

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Bourgeois FT, Murthy S, Mandl KD. Outcome reporting among drug trials registered in ClinicalTrials.gov. Ann Intern Med. 2010;153:158-66.
Reviewers: Buñuel Álvarez JC1, González de Dios J2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Departamento de Pediatría. Hospital General Universitario de Alicante. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 09/09/2010
Acceptance date: 11/09/2010
Publication date: 20/09/2010

Abstract

Authors’ conclusions: Drug trials funded by industry were less likely published within 2 years of study completion and were more likely to report positive outcomes than were trials funded by other sources.

Reviewers’ commentary: Sponsor bias, which may be present despite increasingly stringent regulations governing the design and implementation of a clinical trial, is a reality and must be taken into careful consideration when reading industry funded trials.

How to cite this article

Buñuel Álvarez JC, González de Dios J. Los ensayos clínicos financiados por la industria tienen mayor probabilidad de encontrar resultados favorables al fármaco objeto de estudio. Evid Pediatr. 2010;6:77.

AVC | Critically appraised articles

Bourgeois FT, Murthy S, Mandl KD. Outcome reporting among drug trials registered in ClinicalTrials.gov. Ann Intern Med. 2010;153:158-66.
Reviewers: Buñuel Álvarez JC1, González de Dios J2.
1Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
2Departamento de Pediatría. Hospital General Universitario de Alicante. España.
Correspondence: José Cristóbal Buñuel Álvarez. Email: jcbunuel@gmail.com
Reception date: 09/09/2010
Acceptance date: 11/09/2010
Publication date: 20/09/2010

How to cite this article

Buñuel Álvarez JC, González de Dios J. Los ensayos clínicos financiados por la industria tienen mayor probabilidad de encontrar resultados favorables al fármaco objeto de estudio. Evid Pediatr. 2010;6:77.

References

  1. Argimón Pallàs J, Jiménez Villa J. Métodos de investigación clínica y epidemiológica. 3ª ed. Madrid: Elsevier España S.A.; 2004.
  2. CONSORT Statement Web Site. Transparent reporting of trials [consultado: 8-IX-2010]. Disponible en: http://www.consort-statement.org/home/
  3. DeAngelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, et al. International Committee of Medical Journals Editors. Clinical trial registration: a statement from the International Committee of Medical Journals Editors. JAMA. 2004;292:1363-4.
  4. Jørgensen AW, Hilden J, Gøtzsche PC. Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review. BMJ. 2006;333(7572):782.
  5. González de Dios J, Buñuel Álvarez JC. Las conclusiones de los metaanálisis financiados por la industria farmacéutica deben ser interpretadas con precaución. Evid Pediatr. 2007;3:6.


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