December 2011. Volume 7. Number 4

Isoniazid reduces tuberculosis incidence in HIV-infected children on antiretroviral therapy

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Frigati LJ, Kranzer K, Cotton MF, Schaaf HS, Lombard CJ, Zar HJ. The impact of isoniazid preventive therapy and antiretroviral therapy on tuberculosis in children infected with HIV in a high tuberculosis incidence setting. Thorax. 2011;66:496-501.
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 18/07/2011
Acceptance date: 11/08/2011
Publication date: 14/09/2011

Abstract

Authors' conclusions: Isoniazid (INH) reduces the risk of tuberculosis (TB) in children infected with HIV taking antiretroviral therapy (ART).

Reviewers' commentary: the study has the limitations inherent to cohort studies and some methodological weaknesses. However, given the importance of the results and the potential impact on public health, it seems advisable to use INH associated to ART for preventing TB in HIV patients living in areas of high prevalence of both diseases. More studies are needed to establish the most appropriate regimen and to assess potential adverse effects and the preventive effect in the longer term.

How to cite this article

Gimeno Díaz de Atauri A, Rivas Juesas C. En niños con VIH, la isoniacida asociada a terapia antirretroviral disminuye la incidencia de tuberculosis. Evid Pediatr. 2011;7:83.

AVC | Critically appraised articles

Frigati LJ, Kranzer K, Cotton MF, Schaaf HS, Lombard CJ, Zar HJ. The impact of isoniazid preventive therapy and antiretroviral therapy on tuberculosis in children infected with HIV in a high tuberculosis incidence setting. Thorax. 2011;66:496-501.
Reviewers: Gimeno Díaz de Atauri Á1, Rivas Juesas C2.
1Servicio de Pediatría. Hospital Puerta de Hierro. Madrid. España.
2Servicio de Pediatría. Hospital de Sagunto. Valencia. España.
Correspondence: Álvaro Gimeno Díaz de Atauri. Email: agdrizos@hotmail.com
Reception date: 18/07/2011
Acceptance date: 11/08/2011
Publication date: 14/09/2011

How to cite this article

Gimeno Díaz de Atauri A, Rivas Juesas C. En niños con VIH, la isoniacida asociada a terapia antirretroviral disminuye la incidencia de tuberculosis. Evid Pediatr. 2011;7:83.

References

  1. World Health Organization. International Union Against Tuberculosis and Lung Disease. Guidance for national tuberculosis and HIV programmes on the management of tuberculosis in HIV-infected children: Recommendations for a public health approach [en línea] [fecha depublicación: III-2010] [fecha de consulta: 25-VII-2011]. Disponible en: http://www.theunion.org/index.php/en/resources/scientific-publications/item/759-guidance-for-national-tuberculosis-and-hiv-programmes-on-the-management-of-tuberculosis-in-hiv-infected-children-recommendations-for-a-public-health-approach
  2. Gray DM, Zar H, Cotton M. Impact of tuberculosis preventive therapy on tuberculosis and mortality in HIV-infected children. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006418.
  3.  Zar HJ, Cotton MF, Strauss S, Karpakis J, Hussey G, Schaaf HS et al. Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial. BMJ. 2007;334(7585):136.
  4. Kritzinger FE, Den Boon S, Verver S, Enarson DA, Lombard CJ, Borgdorff MW et al. No decrease in annual risk of tuberculosis infection in endemic area in Cape Town, South Africa. Trop Med Int Health. 2009;14:136-42.
  5. World Health Organization. Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings [en línea] [fecha depublicación: 2011] [fecha de consulta: 25-VII-2011]. Disponible en: http://whqlibdoc.who.int/publications/2011/9789241500708_eng.pdf
14/09/2011

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