December 2013. Volume 9. Number 4

Timolol maleate gel, is useful for the treatment of superficial infantile hemangiomas?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Chan H, McKay C, Adams S, Wargon O. RCT of Timolol Maleate Gel for Superficial Infantile Hemangiomas in 5- to 24-Week-Olds. Pediatrics. 2013;131:e1739-47.

Reviewers: Río-García MD1, Aparicio Rodrigo M2.
1Servicio de Cuidados Intensivos Pediátricos del Hospital Infantil Universitario La Paz. Madrid. España.
2Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Miguel David Río-García. Email: delrio.md@gmail.com
Reception date: 10/09/2013
Acceptance date: 12/09/2013
Publication date: 02/10/2013

Abstract

Authors' conclusions: topical timolol maleate 0.5% gel is a safe an effective option for small superficial infantile hemangiomas that have not ulcerated and are not on mucosal surfaces.

Reviewers' commentary: topical timolol maleate may be useful for whitening and limited volume reduction of small superficial infantile hemangiomas with few side effects, but we don’t know whether this effect remains over time. These results should be confirmed by further studies, given the methodological limitations presented by this one.

How to cite this article

Río-García MD, Aparicio Rodrigo M. ¿Es útil el timolol tópico para el tratamiento de los hemangiomas infantiles superficiales? Evid Pediatr. 2013;9:65.

AVC | Critically appraised articles

Chan H, McKay C, Adams S, Wargon O. RCT of Timolol Maleate Gel for Superficial Infantile Hemangiomas in 5- to 24-Week-Olds. Pediatrics. 2013;131:e1739-47.

Reviewers: Río-García MD1, Aparicio Rodrigo M2.
1Servicio de Cuidados Intensivos Pediátricos del Hospital Infantil Universitario La Paz. Madrid. España.
2Centro de Salud Entreví­as. Área 1. Madrid. España.
Correspondence: Miguel David Río-García. Email: delrio.md@gmail.com
Reception date: 10/09/2013
Acceptance date: 12/09/2013
Publication date: 02/10/2013

How to cite this article

Río-García MD, Aparicio Rodrigo M. ¿Es útil el timolol tópico para el tratamiento de los hemangiomas infantiles superficiales? Evid Pediatr. 2013;9:65.

References

  1. Craiglow BG, Antaya RJ. Management of infantile hemangiomas: current and potential pharmacotherapeutic approaches. Paediatr Drugs. 2013;15:133-8.
  2. Kunzi-Rapp K. Topical propranolol therapy for infantile hemangiomas. Pediatr Dermatol. 2012;29:154-9.
  3. Moehrle M, Léauté-Labrèze C, Schmidt V, Röcken M, Poets CF, Goelz R. Topical timolol for small hemangiomas of infancy. Pediatr Dermatol. 2013;30:245-9.
  4. Chambers CB, Katowitz WR, Katowitz JA, Binenbaum G. A controlled study of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas. Ophthal Plast Reconstr Surg. 2012;28:103-6.
  5. Semkova K, Kazandjieva J. Topical timolol maleate for treatment of infantile haemangiomas: preliminary results of a prospective study. Clin Exp Dermatol. 2013;38:143-6.
02/10/2013

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