March 2016. Volume 12. Number 1

Inhaled xenon does not seem to improve the effect of cooling after birth asphyxia

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermiaalone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016;15:145-53. 

Reviewers: Ochoa Sangrador C1, González de Dios J2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Departamento de Pediatría. Hospital General Universitario de Alicante. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 15/02/2016
Acceptance date: 18/02/2016
Publication date: 24/02/2016

Abstract

Authors´ conclusions:administration of inhaled xenon in patients with neonatal hypoxic-ischemic encephalopathy seems to be feasible and safe, but is unlikely to enhance the neuroprotective effect of cooling.

Reviewers´ commentary:the neuroprotective effect on neonatal asphyxia of inhaled xenon associated with hypothermia, observed in experimental animals, has not been confirmed in clinical use. The procedures and application conditions used in this trial have not reflected improvement in surrogate markers of brain damage nor in short term clinical variables.

How to cite this article

Ochoa Sangrador C, González de Dios J. El xenón inhalado no parece mejorar el efecto de la hipotermia tras la asfixia neonatal. Evid Pediatr. 2016;12:4.

AVC | Critically appraised articles

Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermiaalone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016;15:145-53. 

Reviewers: Ochoa Sangrador C1, González de Dios J2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Departamento de Pediatría. Hospital General Universitario de Alicante. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas2@gmail.com
Reception date: 15/02/2016
Acceptance date: 18/02/2016
Publication date: 24/02/2016

How to cite this article

Ochoa Sangrador C, González de Dios J. El xenón inhalado no parece mejorar el efecto de la hipotermia tras la asfixia neonatal. Evid Pediatr. 2016;12:4.

References

  1. Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J. Xenon and hypothermia combine additively, offerring long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke. 2008;39:1307-13.
  2. Ma D, Hossain M, Chow A, Chow A, Arshad M, Battson RM, et al. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. 2005;58:182-93.

Related Articles

CA | Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón

García-Alix A, Arnaez Solís J. Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón. Evid Pediatr. 2016;12:14.
24/02/2016

Linked Comment

CA | Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón

García-Alix A, Arnaez Solís J. Neuroprotección en la encefalopatía hipóxico-isquémica: ascenso y caída del xenón. Evid Pediatr. 2016;12:14.