September 2016. Volume 12. Number 3

Zika infection in the first trimester increases the risk of fetal microcephaly

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet. 2016. pii: S0140-6736(16)00651-6.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1CS Virgen de África. Sevilla. España.
2CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 14/06/2016
Acceptance date: 16/06/2016
Publication date: 29/06/2016

Abstract

Authors’ conclusions: the results of the comprehensive study allow us to establish a quantitative estimate of the risk of microcephaly in fetuses and newborns whose mothers had Zika virus infection during pregnancy.

Reviewers’ commentary: this ecological study of data of the Zika virus infection, from the epidemic in French Polynesia, provides solid data for claiming that the Zika virus infection in pregnant women (mainly during the first trimester) can determine fetal or neonatal microcephaly in some cases. The embryofetopathy seems to happen in a small percentage of cases, but the infection spreads widely by the population.

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. La infección por zika en el primer trimestre aumenta el riesgo de microcefalia fetal. Evid Pediatr. 2016;12:41.

AVC | Critically appraised articles

Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet. 2016. pii: S0140-6736(16)00651-6.

Reviewers: Ruiz-Canela Cáceres J1, García Vera C2.
1CS Virgen de África. Sevilla. España.
2CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: Juan Ruiz-Canela Cáceres. Email: jruizcanela@gmail.com
Reception date: 14/06/2016
Acceptance date: 16/06/2016
Publication date: 29/06/2016

How to cite this article

Ruiz-Canela Cáceres J, García Vera C. La infección por zika en el primer trimestre aumenta el riesgo de microcefalia fetal. Evid Pediatr. 2016;12:41.

References

  1. Evaluación Rápida del Riesgo de transmisión de enfermedad por el virus Zika en España. Actualización 4 de abril de 2016. En: Centro de Coordinación de Alertas y Emergencias Sanitarias. Ministerio de Sanidad y Consumo [en línea] [consultado el 16/06/2016]. Disponible en: http://goo.gl/kmXeaQ
  2. WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barr syndrome. En: Organización Mundial de la Salud [en línea] [consultado el 16/06/2016]. Disponible en: http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/
  3. Brasil P, Pereira JP Jr, Gabaglia CR, Damasceno L, Wakimoto M, Ribeiro Nogueira RM, et al. Zika virus infection in pregnant women in Rio de Janeiro - preliminary report. N Engl J Med. 2016. [en prensa].
  4. Rodrigues LC. Microcephaly and Zika virus infection. Lancet. 2016;387:2070-2.

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