June 2018. Volume 14. Number 1

Are antidepressants useful for functional abdominal pain?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Zar-Kessler CAM, Belkind-Gerson J, Bender S, Kuo BM. Treatment of functional abdominal pain with antidepressants: benefits, adverse effects, and the gastroenterologist’s role. J Pediatr Gastroenterol Nutr. 2017;65:16-21.

Reviewers: Pérez González E1, Molina Arias M2.
1Hospital Macarena. Sevilla. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Elena Pérez González. Email: pg.elena@gmail.com
Reception date: 22/06/2018
Acceptance date: 27/06/2018
Publication date: 04/07/2018

Abstract

Authors’ conclusions: patients had more response to serotonin reuptake inhibitors than to tricyclic antidepressants, independently of the associated psychiatric component. They give little importance to the gastrointestinal symptoms caused by the drug that could be the cause of the withdrawal of the medication.

Reviewers’ commentary: antidepressants appear to be effective for the treatment of functional abdominal pain, with a therapeutic advantage of serotonin reuptake inhibitors over tricyclics. However, given the methodological limitations of the study, the lack of concordance with other available data and the high percentage of adverse effects, it seems prudent to wait for larger and higher quality studies to be able to recommend its use in this functional pathology.

How to cite this article

Pérez González E, Molina Arias M. ¿Son útiles los antidepresivos para el dolor abdominal funcional? Evid Pediatr. 2018;14:4.

AVC | Critically appraised articles

Zar-Kessler CAM, Belkind-Gerson J, Bender S, Kuo BM. Treatment of functional abdominal pain with antidepressants: benefits, adverse effects, and the gastroenterologist’s role. J Pediatr Gastroenterol Nutr. 2017;65:16-21.

Reviewers: Pérez González E1, Molina Arias M2.
1Hospital Macarena. Sevilla. España.
2Servicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid. España.
Correspondence: Elena Pérez González. Email: pg.elena@gmail.com
Reception date: 22/06/2018
Acceptance date: 27/06/2018
Publication date: 04/07/2018

How to cite this article

Pérez González E, Molina Arias M. ¿Son útiles los antidepresivos para el dolor abdominal funcional? Evid Pediatr. 2018;14:4.

04/07/2018

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