March 2010. Volume 6. Number 1

The prophylactic administration of acetaminophen appears to decrease post-vaccination fever in infants, but it may reduce the immune response

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Prymula R,Siegrist C-A,Chlibek R,Zemlickova H,Smetana J,Lommel P,et al.Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children:two open-label,randomized,controlled trials. Lancet 2009;374:1339-50
Reviewers: Cuestas Montañés E1, Buñuel Álvarez JC2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 23/02/2010
Acceptance date: 03/03/2010
Publication date: 25/03/2010

Abstract

Authors’ conclusions: although the prophylactic administration of acetaminophen at the time of vaccination decreases significantly the febrile reactions, it should not be routinely recommended because it reduces the antibody responses to several vaccine antigens.

Reviewers’ commentary: these findings should be confirmed in other independent, randomized, blind, placebo controlled trials. Until consistent and conclusive results are obtained, acetaminophen can be used in selected cases.

How to cite this article

Cuestas Montañés E, Buñuel Álvarez JC. En lactantes, la administración de paracetamol profiláctica parece disminuir la fiebre post-vacunal, aunque pudiendo reducir la respuesta inmune. Evid Pediatr. 2010;6:12.

AVC | Critically appraised articles

Prymula R,Siegrist C-A,Chlibek R,Zemlickova H,Smetana J,Lommel P,et al.Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children:two open-label,randomized,controlled trials. Lancet 2009;374:1339-50
Reviewers: Cuestas Montañés E1, Buñuel Álvarez JC2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2Àrea Bàsica de Salut Girona-4. Institut Català de la Salut. Girona. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 23/02/2010
Acceptance date: 03/03/2010
Publication date: 25/03/2010

How to cite this article

Cuestas Montañés E, Buñuel Álvarez JC. En lactantes, la administración de paracetamol profiláctica parece disminuir la fiebre post-vacunal, aunque pudiendo reducir la respuesta inmune. Evid Pediatr. 2010;6:12.

References

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  2. Ipp MM, Gold R, Greenberg S, Goldbach M, Kupfert BB, Lloyd DD, Maresky DC,Saunders N, Wise SA. Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheria-pertussis-tetanus toxoids-polio vaccine. Pediatr Infect Dis J. 1987;6:721-5.
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25/03/2010

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