September 2007. Volume 3. Number 3

Exclusion criteria of randomized controlled trials (RCTs) are not always justified and such exclusions may impair the generalizability of RCT results

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Van Spall HGC; Toren A, Kiss A, Fowler RA. Eligibility criteria of randomized controlled trials publisher in high-impact general medical journals. JAMA. 2007;297:1233-40
Reviewers: Martín Muñoz P1, Fernández Rodríguez M2.
1 Hospitales Universitarios Virgen del Rocí­o. Sevilla. España.
2Centro de Salud de Potes. Madrid. España.
Correspondence: Pedro Martín Muñoz. Email: pedromartinm@telefonica.net
Reception date: 6/05/2007
Acceptance date: 22/05/2007
Publication date: 01/09/2007

Abstract

How to cite this article

Martin Muñoz P, Fernández Rodríguez M. Los criterios de exclusión presentes en los ensayos clínicos no siempre están justificados y afectan a la posterior generalización de sus resultados. Evid Pediatr. 2007;3:62.

AVC | Critically appraised articles

Van Spall HGC; Toren A, Kiss A, Fowler RA. Eligibility criteria of randomized controlled trials publisher in high-impact general medical journals. JAMA. 2007;297:1233-40
Reviewers: Martín Muñoz P1, Fernández Rodríguez M2.
1 Hospitales Universitarios Virgen del Rocí­o. Sevilla. España.
2Centro de Salud de Potes. Madrid. España.
Correspondence: Pedro Martín Muñoz. Email: pedromartinm@telefonica.net
Reception date: 6/05/2007
Acceptance date: 22/05/2007
Publication date: 01/09/2007

How to cite this article

Martin Muñoz P, Fernández Rodríguez M. Los criterios de exclusión presentes en los ensayos clínicos no siempre están justificados y afectan a la posterior generalización de sus resultados. Evid Pediatr. 2007;3:62.

References

  1. Gurwitz JH, Col NF, Avorn J. The exclusion of the elderly and women from trials in acute myocardial infarction. JAMA. 1992;268:1417-22.
  2. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001;286:708-13.
  3. Wilson JT. An update on the therapeutic orphan. Pediatrics 1999;104:585-90.
  4. Committee on drugs. Uses of drugs not described in the package insert (off-label uses). Pediatrics. 2002;110:181-3.
01/09/2007

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