October 2009. Volume 5. Number 3

Treating acute broncholitis in infants with a combined therapy of nebulized epinephrine and oral dexamethasone could reduce hospital admissions

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Plint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, et al; Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360:2079-89
Reviewers: Aizpurua Galdeano P1, Ortega Páez E2.
1ABS 7 La Salut Badalona. Badalona. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 28/07/2009
Acceptance date: 04/08/2009
Publication date: 10/09/2009

Abstract

Authors' conclusions: Among infants with bronchiolitis treated in the emergency department, combined therapy with dexamethasone and epinephrine may significantly reduce hospital admissions.

Reviewers' commentary: Given the current recommendations of the clinical practice guidelines, the results of this study (number needed to treat [NNT] of 11, with a wide confidence interval), its methodological limitations and the potential side effects of treating infants with high doses of dexamethasone, it does not seem sensible to change our therapeutic approach to bronchiolitis.

How to cite this article

Aizpurua Galdeano P, Ortega Páez E. En lactantes con bronquiolitis aguda, el uso combinado de adrenalina nebulizada y dexametasona oral podría disminuir los ingresos hospitalarios. Evid Pediatr. 2009;5:69.

AVC | Critically appraised articles

Plint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, et al; Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360:2079-89
Reviewers: Aizpurua Galdeano P1, Ortega Páez E2.
1ABS 7 La Salut Badalona. Badalona. España.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Pilar Aizpurua Galdeano. Email: 19353pag@gmail.com
Reception date: 28/07/2009
Acceptance date: 04/08/2009
Publication date: 10/09/2009

How to cite this article

Aizpurua Galdeano P, Ortega Páez E. En lactantes con bronquiolitis aguda, el uso combinado de adrenalina nebulizada y dexametasona oral podría disminuir los ingresos hospitalarios. Evid Pediatr. 2009;5:69.

References

  1. Brand PL, Baraldi E, Bisgaard H, Boner AL, Castro-Rodriguez JA, Custovic A, et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J. 2008;32:1096-110.
  2. Los corticoides no son eficaces en la bronquiolitis aguda. Ochoa Sangrador C, Castro Rodríguez JA. Evid Pediatr. 2007;3:91.
  3. La administración de salbutamol o adrenalina racémica en nebulización no disminuye la duración del ingreso ni la dificultad respiratoria en la bronquiolitis. Aizpurua Galdeano P. Evid Pediatr. 2006;2:13.
  4. Scottish Intercollegiate Guidelines Network (SIGN). Bronchiolitis in children. A national clinical guideline. Edinburgh ( Scotland ): Scottish Intercollegiate Guidelines Network (SIGN); 2006 Nov. 41 p. (SIGN publication; no. 91).
10/09/2009

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