December 2010. Volume 6. Number 4

Childhood cancer survivors have a higher mortality in adulthood than the general population

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, Jenney ME et al; British Childhood Cancer Survivor Study Steering Group. Long-term cause-specific mortality among survivors of childhood cancer. JAMA. 2010;304:172-9.
Reviewers: Olivares Grohnert M1, Cuestas Montañés E2.
1Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile. Santiago. Región Metropolitana. Chile.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Manuel Olivares Grohnert. Email: molivare@inta.cl
Reception date: 08/10/2010
Acceptance date: 29/10/2010
Publication date: 04/11/2010

Abstract

Authors´ conclusions: the findings from this large-scale population-based study indicate that in childood cancer survivors, the mortality for second primary tumors, circulatory diseases and respiratory diseases is increased beyond 25 years from diagnosis, which suggest a substantial increase in premature deaths.

Reviewers´ commentary: childhood cancer survivors have a lower life expectancy in adulthood, even after 25 years of diagnosis. Nevertheless, it is not possible to establish with this study the risk attributable to the initial disease and its associated treatment.

How to cite this article

Olivares Grohnert M, Cuestas Montañés E. Los supervivientes de cáncer infantil tienen una mayor mortalidad en la edad adulta que la población general. Evid Pediatr. 2010;6:85.

AVC | Critically appraised articles

Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, Jenney ME et al; British Childhood Cancer Survivor Study Steering Group. Long-term cause-specific mortality among survivors of childhood cancer. JAMA. 2010;304:172-9.
Reviewers: Olivares Grohnert M1, Cuestas Montañés E2.
1Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile. Santiago. Región Metropolitana. Chile.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Manuel Olivares Grohnert. Email: molivare@inta.cl
Reception date: 08/10/2010
Acceptance date: 29/10/2010
Publication date: 04/11/2010

How to cite this article

Olivares Grohnert M, Cuestas Montañés E. Los supervivientes de cáncer infantil tienen una mayor mortalidad en la edad adulta que la población general. Evid Pediatr. 2010;6:85.

References

  1. Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL et al. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649: Bethesda, MD;1999.
  2. Armstrong GT, Liu Q, Yasui Y, Neglia JP, Leisenring W, Robison LL et al. Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J Clin Oncol. 2009;27:2328-38.
  3. Dama E, Pastore G, Mosso ML, Ferrante D, Maule MM, Magnani C et al. Late deaths among five-year survivors of childhood cancer: a population-based study in Piedmont Region, Italy. Haematologica. 2006;91:1084-91.
  4. MacArthur AC, Spinelli JJ, Rogers PC, Goddard KJ, Abanto ZU, McBride ML. Mortality among 5-year survivors of cancer diagnosed during childhood or adolescence in British Columbia, Canada. Pediatr Blood Cancer. 2007;48:460-7.
  5. Henderson TO, Friedman DL, Meadows AT. Childhood cancer survivors: transition to adult-focused risk-based care. Pediatrics. 2010;126:129-36.

04/11/2010

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