Authors’ conclusions: results of this study support the existence of an association between obesity and the presence of adenovirus 36 antibodies in children. If a causal effect could be proven, this fact would have important implications for prevention and treatment of childhood obesity.
Reviewers’ commentary: data provided by the study show that there are important confounding factors such as age, which could be directly related to the presence or absence of anti-adenovirus 36 and have not been considered in the statistical analysis. Variables such as caloric intake or physical activity have not been taken intoaccount. Therefore, we can not conclude the presence of a causal association.