Authors' conclusions: there is little evidence for or against the use of the ibuprofen and paracetamol combination, compared to the isolated use of one of them to relieve fever and the discomfort associated with it. In this context, it is prudent not to recommend the use of the combination therapy with both drugs to treat this clinical sign and use, if necessary, only one of them.
Reviewers' commentary: the results of this systematic review, recommend us to avoid prescribing the combined use of antipyretics as there is no evidence of effectiveness or safety data supporting its use. In addition, the role of antipyretics is to treat a symptom which by itself causes no harm, and it is an ally to control the infection. In this context, when treatment is really necessary, it is now advisable to treat fever with a single drug.