Authors' conclusions: efficiencyof screening for congenital adrenal hyperplasia 21-hydroxylase deficiency was moderate in term infants and very low inpreterm infants. The authors recommend the discontinuation of screening as has been done so far, in premature infants.
Reviewers' commentary: performance of screening for congenital adrenal hyperplasia in infants born at term, it seems appropriate. Not so in preterm infants, where there is a high rate of false positives, which calls into question its inclusion within the neonatal screening. There are specific techniques but also more expensive, which could improve the effectiveness of screening. Should do more studies to rate this as well as economic studies that assess whether increase defficiency,offsets the increase in spending would the implementation of these screening techniques.