June 2016. Volume 12. Number 2

The use of antidepressants during pregnancy may slightly increase the risk of autism

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Boukhris T, Sheehy O, Mottron L, Bérard A. Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatr. 2016;170:117-24.

Reviewers: Cuestas Montañés E1, Buñuel Álvarez JC2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2CS Villamayor de Gállego. Zaragoza. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 07/06/2016
Acceptance date: 09/06/2016
Publication date: 22/06/2016

Abstract

Authors’ conclusions: the use of antidepressants, specifically selective serotonin reuptake inhibitors, during the second and/or third trimester of gestation increases the risk of autism spectrum disorder in children.

Reviewers’ commentary: antidepressants should be restricted during gestation and used only by those pregnant women properly diagnosed with mental disorders that do not improve sufficiently with only non-pharmacological therapies, like psychotherapy. For this reason, it is of vital importance to have made a correct diagnosis of the specific mental problem involved. As long as this situation remains, and the association continues as not fully clarified, we must strongly advise prudence and caution concerning the use of antidepressants during pregnancy.

How to cite this article

Cuestas Montañés E, Buñuel Álvarez JC. El consumo de antidepresivos durante el embarazo podría incrementar levemente el riesgo de autismo. Evid Pediatr. 2016;12:22.

AVC | Critically appraised articles

Boukhris T, Sheehy O, Mottron L, Bérard A. Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatr. 2016;170:117-24.

Reviewers: Cuestas Montañés E1, Buñuel Álvarez JC2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2CS Villamayor de Gállego. Zaragoza. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 07/06/2016
Acceptance date: 09/06/2016
Publication date: 22/06/2016

How to cite this article

Cuestas Montañés E, Buñuel Álvarez JC. El consumo de antidepresivos durante el embarazo podría incrementar levemente el riesgo de autismo. Evid Pediatr. 2016;12:22.

References

  1. Grupo de Trabajo de la Guía de Práctica Clínica para el Manejo de Pacientes con Trastornos del Espectro Autista en Atención Primaria. Guía de Práctica Clínica para el Manejo de Pacientes con Trastornos del Espectro Autista en Atención Primaria. Plan de Calidad para el Sistema Nacional de Salud del Ministerio de Sanidad y Política Social. Unidad de Evaluación de Tecnologías Sanitarias. Agencia Laín Entralgo; 2009. Guías de Práctica Clínica en el SNS: UETS N.º 2007/5-3 [consultado el 30/05/2016]. Disponible en: http://www.guiasalud.es/GPC/GPC_462_Autismo_Lain_Entr_compl.pdf
  2. Jimenez-Solem E, Andersen JT, Petersen M, Broedbaek K, Andersen NL, Torp-Pedersen C, et al. Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study. PLoS One. 2013;8:e63034.
  3. Bérard A, Sheehy O, Damase-Michel C, Crespin S. Paroxetine use during pregnancy and perinatal outcomes including types of cardiac malformations in Quebec and France: a short communication. Curr Drug Saf. 2012;7:207-10.
  4. Sørensen MJ, Grønborg TK, Christensen J, Parner ET, Vestergaard M, Schendel D, et al. Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin Epidemiol. 2013;5:449-59.
  5. Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ. 2013;346:f2059.
22/06/2016

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